Managing Malignant Diseases with Imutrex (Methotrexate)
Imutrex (Methotrexate) 25mg tablets, an essential cytotoxic antimetabolite, play a pivotal role in combating malignant tissue with high cell turnover. By irreversibly binding with dihydrofolate reductase and inhibiting nucleic acid synthesis, Imutrex effectively hinders cell division. While it targets malignant cells, it may adversely affect other rapidly dividing normal tissues, necessitating careful consideration of its usage.
Description and Action
Imutrex’s mode of action revolves around its function as a folic acid antagonist, leading to a deficiency that hinders nucleic acid synthesis. Rapidly absorbed and predominantly excreted through the kidneys, its effectiveness depends on factors such as renal function and the dose administered. This potent medication finds utility in managing various malignant diseases, including acute lymphoblastic leukemia, choriocarcinoma, and psoriasis.
Indications and Contraindications
Imutrex (Methotrexate) is particularly effective in the treatment of lymphosarcoma, Burkitt’s lymphoma, osteogenic sarcoma, and tumors in various organs. Pregnant women, individuals with poor nutrition, serious renal or liver disorders, and those with bone marrow hypoplasia or blood-related issues should avoid this treatment. Close monitoring and regular blood counts are crucial during Imutrex therapy, and adjustments to the dosage may be necessary based on observed toxicity.
Undesirable Effects and Precautions
Patients undergoing Imutrex therapy may experience a range of adverse effects, including gastrointestinal disturbances, bone marrow depression, and an increased susceptibility to long bone fractures. Regular hematological assessments and close vigilance for signs of toxicity are imperative. Patients with impaired renal function, infections, peptic ulcers, or debility should exercise caution. Adjust the dosage accordingly to mitigate potential risks associated with its usage.
Dosage Guidelines
In adult ALL, doctors recommend 33mg of Imutrex daily per square meter of skin, taken with prednisolone. The maintenance dosage for achieving remission is typically 20-30 mg/M2 of body surface orally twice a week.
Mycosis Fungoides treatment with Imutrex involves taking 25mg to 10mg daily by mouth for weeks or months, tailored to each patient’s needs. Due to potential risks and benefits, close medical supervision is essential, ensuring adjustments are made to optimize the treatment for each individual’s overall health and condition.
Derma.pk, an online skin care store backed by Pakistan-renowned dermatologists, provides Imutrex 100 Tablets (Methotrexate 2.5mg) to help manage malignant diseases. We also have an in-house Pharmacist who can guide you about any product usage and provide in-depth information. At derma.pk, we only offer 100% original and imported products from Pakistan and internationally renowned brands. We provide COD (cash on delivery) all over Pakistan and accept credit card, debit card, and bank transfer payments. You can place your order via WhatsApp at 923205999650.
