{"product_id":"delnib-2-10g-cream","title":"Delnib 2% Cream for Chronic Hand Eczema (Delgocitinib) 10g","description":"\u003ch2\u003eAbout Delnib 2% Cream\u003c\/h2\u003e\n\u003cp\u003eDelnib 2% Cream by Horizon Pharmaceuticals is a topical \u003cstrong\u003epan-JAK inhibitor\u003c\/strong\u003e containing Delgocitinib 2% (20 mg\/g). By simultaneously inhibiting JAK1, JAK2, JAK3, and TYK2, it suppresses the key inflammatory cytokines — IL-4, IL-13, IL-17A, and IFN-γ — that drive the persistent itch, pain, and skin barrier damage characteristic of chronic hand eczema (CHE). Delivering active relief directly to affected skin, Delnib minimises systemic exposure compared to oral JAK inhibitors.\u003c\/p\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePan-JAK Inhibition:\u003c\/strong\u003e Blocks all four JAK enzymes simultaneously, providing comprehensive suppression of the inflammatory cascade underlying chronic hand eczema.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Proven:\u003c\/strong\u003e Phase III DELTA 1 \u0026amp; 2 trials demonstrated up to 37.7% treatment success versus vehicle after 16 weeks of twice-daily application.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRelieves Itch \u0026amp; Pain:\u003c\/strong\u003e Significantly reduces Hand Eczema Symptom Diary (HESD) scores, including itch intensity and pain — two of the most debilitating symptoms of CHE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTopical \u0026amp; Targeted:\u003c\/strong\u003e Localised action on the hands with minimal systemic absorption, a safer profile than oral JAK inhibitors for hand-confined disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSustained Efficacy:\u003c\/strong\u003e Long-term safety and efficacy demonstrated for up to 52 weeks in the Phase III DELTA 3 open-label extension trial.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cp\u003eDelnib 2% Cream is indicated for \u003cstrong\u003emoderate-to-severe chronic hand eczema\u003c\/strong\u003e in adults, particularly those with an inadequate response to, or intolerance of, topical corticosteroids. It forms part of the \u003ca href=\"\/collections\/eczema\"\u003eEczema Care\u003c\/a\u003e range at Derma.pk and sits alongside other \u003ca href=\"\/collections\/cream-and-ointment\"\u003emedicated creams\u003c\/a\u003e for targeted skin condition management. Use under the supervision of a qualified dermatologist.\u003c\/p\u003e\n\n\u003ch2\u003eComposition\u003c\/h2\u003e\n\u003cp\u003eEach gram contains Delgocitinib 20 mg (2%) in a cream base. Available in a 10 g tube. Browse the full \u003ca href=\"\/collections\/skin-care\"\u003eSkin Care\u003c\/a\u003e range at Derma.pk for more dermatologist-recommended products.\u003c\/p\u003e\n\n\u003ch2\u003ePrecautions\u003c\/h2\u003e\n\u003cp\u003eFor external use only. Avoid use on infected skin without appropriate antimicrobial cover. Not recommended during pregnancy or lactation without medical advice. Discontinue and consult your dermatologist if adverse reactions occur.\u003c\/p\u003e","brand":"Horizon","offers":[{"title":"Default Title","offer_id":46483168723117,"sku":"DER0000006848","price":2500.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0632\/2015\/4541\/files\/Delnib_2_Cream_10g.jpg?v=1782820187","url":"https:\/\/derma.pk\/products\/delnib-2-10g-cream","provider":"Derma.pk","version":"1.0","type":"link"}