Terbisan Cream: A Comprehensive Overview
Composition:
TERBISAN CREAM (1% w/w):
Terbinafine HCI USP in a Cream base
Physiochemical Properties:
Terbinafine
Hydrochloride: Broad spectrum antifungal, fungicidal at low concentrations,
soluble in organic solvents, slightly soluble in water
Mechanism of Action:
Terbinafine inhibits
squalene epoxidase, disrupting ergosterol synthesis, leading to damaged fungal
cell membranes Fungicidal action sets it apart from fungistatic alternatives
Pharmacokinetics:
Cream: Minimal
absorption (less than 5%) after topical application
Indications:
Cream: For fungal
infections of the skin caused by various pathogens, including candida albican
and pityriasis versicolor
Dosage & Administration:
Cream: Applied twice
daily, duration varies for different infections
Contraindications:
Hypersensitivity to cream ingredient
Precautions:
Special caution for
tablets in patients with chronic liver dysfunction or impaired renal failure
Cream for external
use only; avoid contact with eyes
Pregnancy and Lactation:
Limited data in
pregnant women; tablets not recommended during pregnancy Excreted in breast
milk; not recommended in nursing mothers
Side Effects:
- Cream: Occasional
redness, itching, and stinging at the application site
Over dosage:
cream: Symptoms
include nausea, vomiting, abdominal pain, dizziness, rash, frequent urination,
and headache Treatment involves eliminating the drug and symptomatic support
Presentation:
Cream: Terbisan 1%,
10gm collapsible aluminum tube
Storage:
Cream: Store below
30 °C, for external use only
To be sold on prescription of a registered medical
practitioner only For oral use (tablets) and external use (cream) only
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