Terbisan Cream: A Comprehensive Overview
?Composition:
TERBISAN CREAM (1% w/w):
Terbinafine HCI USP in a Cream base
?Physiochemical Properties:
?Terbinafine
Hydrochloride: Broad spectrum antifungal, fungicidal at low concentrations,
soluble in organic solvents, slightly soluble in water
?Mechanism of Action:
?Terbinafine inhibits
squalene epoxidase, disrupting ergosterol synthesis, leading to damaged fungal
cell membranes Fungicidal action sets it apart from fungistatic alternatives
?Pharmacokinetics:
?Cream: Minimal
absorption (less than 5%) after topical application
?Indications:
Cream: For fungal
infections of the skin caused by various pathogens, including candida albican
and pityriasis versicolor
?Dosage & Administration:
? Cream: Applied twice
daily, duration varies for different infections
?Contraindications:
?Hypersensitivity to cream ingredient
?Precautions:
?Special caution for
tablets in patients with chronic liver dysfunction or impaired renal failure
?Cream for external
use only; avoid contact with eyes
?Pregnancy and Lactation:
?Limited data in
pregnant women; tablets not recommended during pregnancy Excreted in breast
milk; not recommended in nursing mothers
?Side Effects:
- ?Cream: Occasional
redness, itching, and stinging at the application site
?Over dosage:
?cream: Symptoms
include nausea, vomiting, abdominal pain, dizziness, rash, frequent urination,
and headache Treatment involves eliminating the drug and symptomatic support
Presentation:
?Cream: Terbisan 1%,
10gm collapsible aluminum tube
?Storage:
? Cream: Store below
30 ?C, for external use only
?To be sold on prescription of a registered medical
practitioner only For oral use (tablets) and external use (cream) only
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