Terbiderm (Terbinafine Tablets USP) ?Oral Antifungal Agent

Composition:

• ?Terbiderm Forte Tablets
• Each tablet contains Terbinafine 250mg (as Terbinafine HCI
  BP)

Properties:

• ?Broadspectrum antifungal activity
• ?Fungicidal and fungistatic effects
• ?Targets dermatophytes, molds, and dimorphic fungi
• ?Interferes with fungal sterol biosynthesis
• Inhibits squalene epoxidase in fungal cell membrane
• Concentrates in skin, hair, and nails

Pharmacokinetics:

• ?Peak plasma
  concentrations achieved within 2 hours
• ?Moderately affected
  by food
• ?Strong binding to
  plasma proteins (99%)
• ?Rapid diffusion
  through the dermis and stratum corneum
• ?Secreted in sebum,
  achieving high concentrations in hair follicles
• ?Distributed into the
  nail plate in the first few weeks of therapy
• ?Eliminated through
  urine

Indications:

• ?Fungal infections of
  the skin, hair, and nails
• ?Dermatophytes
  (Trichophyton, Microsporum, Epidermophyton)
• ?Candida skin
  infections
• ?Onychomycosis (fungal
  nail infection)
• ?Not effective for
  pityriasis versicolor
• Dosage and Administration:
• ?Dosage varies by age
  group and indication
• ?Duration of treatment
  varies by the severity of the infection
• ?Best results when
  taken with meals
• ?Specific regimens for
  tinea corporis, cruris, pedis, cutaneous candidiasis, hair and scalp
  infections, and onychomycosis

Contraindications:

?Hypersensitivity to
terbinafine

Precautions:

• ?Use with caution in
  patients with chronic liver dysfunction or impaired renal function
• ?Pregnancy: Use only
  if potential benefits outweigh risks
• ?Terbinafine is
  excreted in breast milk; avoid breastfeeding during oral treatment

Interactions:

• ?Negligible impact on
  drugs metabolized via the cytochrome P450 system
• ?Possible menstrual
  irregularities when used with oral contraceptives
• ?May be accelerated by
  drugs inducing metabolism or inhibited by drugs inhibiting cytochrome P450

Side Effects:

• ?Mild to moderate and
  transient
• ?Common side effects
  include gastrointestinal symptoms and nonserious skin reactions
• ?Rare cases of serious
  skin reactions, taste disturbances, and hepatobiliary dysfunction
• ?Isolated cases of
  hematological disorders (neutropenia, thrombocytopenia)

Overdosage:

• ?Rare, with reported
  cases of nausea, epigastric pain, and dizziness
• ?Treatment includes
  activated charcoal and symptomatic support

TERBIDERM FORTE TABLETS Facts:

• ?Terbinafine is a fastacting
  antifungal for skin and nail infections
• ?High cure rates (over
  90%) for dermatophyte infections
• ?Most effective in
  treating fungal nail infections within 3 to 6 months
• ?Regimen duration
  depends on the type and severity of infection
• ?Take terbinafine with
  meals for best results

• Follow your doctor’s advice for a healthier, infectionfree
  life Terbiderm is your solution for fungal skin and nail infections