Augmentin (Co-amoxiclav) 156.25 mg/5 ml Suspension  Detailed Information

 Introduction

 Augmentin, known generically as Co-amoxiclav, is a medication used to treat a wide range of bacterial infections. It combines two active ingredients: amoxicillin and clavulanic acid. This article provides comprehensive information about Augmentin, its composition, clinical
particulars, dosage, contraindications, and more

 Composition

 Augmentin is available in various forms, including tablets and suspension. Here’s a breakdown of its composition:

 Augmentin 375 mg Tablets:

     Contains 250 mg amoxicillin (as amoxicillin trihydrate U.S.P) and 125 mg clavulanic acid (as the potassium salt B.P)

 Augmentin 625 mg Tablets:

     Contains 500 mg amoxicillin (as amoxicillin trihydrate U.S.P) and 125 mg clavulanic acid (as the potassium salt B.P)

 Augmentin 1 g Tablets:

     Contains 875 mg amoxicillin (as amoxicillin trihydrate U.S.P) and 125 mg clavulanic acid (as the potassium salt B.P)

 Augmentin Suspension 156.25 mg/5 mL (when reconstituted):

     Contains 125 mg amoxicillin (as amoxicillin trihydrate U.S.P) and 31.25 mg clavulanic acid (as the potassium salt B.P) per
5 ml

 Clinical Particulars

 Augmentin is a broad-spectrum antibiotic effective against a wide range of bacterial pathogens. It is commonly used to treat infections in the upper respiratory tract, lower respiratory tract, dental infections, genitourinary tract, skin and soft tissue, bone and joint, and other infections

 Indications

 Augmentin is prescribed for various conditions, including:

•  Upper respiratory tract infections (e.g., tonsillitis, sinusitis, otitis media)
•  Lower respiratory tract infections (e.g., bronchopneumonia)
•  Dental infections (e.g., dentoalveolar abscess)
•  Genitourinary tract infections (e.g., cystitis, pyelonephritis)
•  Skin and soft tissue infections (e.g., cellulitis, abscesses)
•  Bone and joint infections (e.g., osteomyelitis)
•  Other infections (e.g., intraabdominal sepsis)

 Dosage and Administration

 The recommended dosage of Augmentin depends on the severity of the infection and the patient’s age:

   Adults and Children over 12 years:

•    Mild to moderate infections: One Augmentin 375 mg tablet every 8 hours or one 625 mg tablet every 12 hours
•    Severe infections: One Augmentin 1 g tablet every 12 hours or one 625 mg tablet every 8 hours

   Children (2 years and over):

•    The dosage varies based on the child’s weight and the severity of the infection. Consult a healthcare provider for appropriate dosing
•  Augmentin can be taken with or without food, but it’s recommended to take it at the start of a meal to minimize gastrointestinal discomfort

 Contraindications

 Augmentin should not be used in individuals with a history of hypersensitivity to beta lactam antibiotics, penicillin, cephalosporins, or any of its components. It’s also contraindicated in patients with a history of Augmentin associated jaundice/hepatic dysfunction

 Warnings and Precautions

•    Hypersensitivity: This syrup should be used with caution in individuals with a history of
  penicillin hypersensitivity. Discontinue treatment if you experience hypersensitivity reactions as serious allergic reactions may occur.
•    Gastrointestinal Effects: Diarrhea may occur during or after antibiotic use, and treatment
  should be discontinued if significant diarrhea occurs
•    Liver Function: Use this cautiously in patients showing signs of liver dysfunction, and regularly monitor their liver function.
•    Renal Impairment: Dosage adjustments are necessary for patients with renal impairment

 Adverse Reactions

 Syrup may cause various adverse reactions, including gastrointestinal symptoms, skin rash, headache, and, rarely, serious allergic reactions. If any adverse reactions occur, it’s important to seek medical attention

 Storage

Store this syrup in a dry place, shield it from moisture, and avoid freezing it. After reconstituting, keep the suspension in a refrigerator and use it within 7 days.

 Conclusion

 Augmentin is a widely used antibiotic effective against a range of bacterial infections. Use it cautiously and be mindful of potential side effects and contraindications, although it’s generally safe and well-tolerated by patients. Always follow the guidance of a healthcare provider when taking syrup