Hyderquin Plus Cream: Your Solution for Skin Discoloration and Melasma

Introduction

 Hyderquin Plus Cream is a dermatological formulation that
combines the power of three active ingredients: Hydroquinone, Fluocinolone
Acetonide, and Tretinoin. This cream is designed for topical application and is
particularly effective in treating moderate to severe melasma of the face. With
a balanced composition, Hyderquin Cream provides a comprehensive solution
to address skin discoloration and related concerns.

Composition

 Hyderquin Plus Cream comprises the following active
ingredients per gram:

 Hydroquinone 4% w/w

 Fluocinolone
Acetonide 0.01% w/w

 Tretinoin 0.05% w/w

These components work together to combat melasma and improve
skin health.

Clinical Pharmacology

 Hydroquinone:

A depigmenting agent that interrupts the melanin synthesis pathway, reducing skin
pigmentation.

 Fluocinolone
Acetonide:

A synthetic corticosteroid with antiinflammatory properties, aiding in melasma treatment.

 Tretinoin:

Helps to improve skin texture and pigmentation.

Minimal systemic absorption of these ingredients occurs,
ensuring safety and effectiveness.

 Indications and Usage

 Hyderquin Cream is indicated for the shortterm,
intermittent treatment of moderate to severe melasma on the face. To maximize
effectiveness, it should be used in conjunction with sunavoidance measures and
sunscreen.

Contraindications

 This cream is contraindicated for individuals with a history
of hypersensitivity, allergies, or intolerance to any of its components.

 Warnings

 Sodium Metabisulfite:

Hyderquin Cream contains sodium metabisulfite, which may cause allergic
reactions. Prevalence in the general population is low, but caution should be
exercised.

 Hydroquinone:

Prolonged use may lead to exogenous ochronosis, prompting discontinuation of
treatment.

 Hypersensitivity:

Allergic contact dermatitis has been reported in some cases. If irritation or
severe side effects occur, discontinue use.

Precautions

 Skin Irritation:

Some local skin irritation, such as redness or mild burning, is normal. It does not
necessarily indicate a problem.

 Sun Protection:

Sun avoidance and sunscreen are essential during treatment to prevent repigmentation.

 Mucosa: Avoid applying the cream near sensitive areas such as the eyes, nose, and mouth.

 Excessive Use:

Overuse may result in marked redness, peeling, or discomfort.

 Laboratory Tests

 In case of suspected HPA axis suppression, specific tests can help evaluate the condition.

Dosage and Administration

 Apply Hyderquin Plus Cream once daily at night, at least 30
minutes before bedtime. Gently cleanse the skin, pat it dry, and apply a thin
layer of the cream to the hyperpigmented areas. Avoid occlusive dressing and
use sunscreen during the day.

How Supplied

 Hyderquin Plus Cream comes in a 15g aluminum collapsible
tube.

 Instructions

•  Keep out of reach of
  children.
•  Protect from light,
  heat, and freezing.
•  Store below 25 °C.
•  Use as directed by
  your physician.

In summary, Hyderquin Plus Cream is a comprehensive solution
for skin discoloration, offering effective treatment for melasma when used as
directed. It combines active ingredients to provide maximum benefits while
ensuring patient safety.