ORATANE TABLETS
ORATANE TABLETS (ISOTRETIOIN) 20mg PACK OF 30 SOFT GELATIN CAPSULES CRYSTOLITE
ORATANE TABLETS (ISOTRETIOIN) 20mg PACK OF 30 SOFT GELATIN CAPSULES CRYSTOLITE

ORATANE TABLETS (ISOTRETIOIN) 20mg PACK OF 30 SOFT GELATIN CAPSULES

ORATANE TABLETS (Isotretinoin, soft gelatin capsule, 20mg by crystolite, Each Pack Contains 30 Capsules)

Oratane Soft Gelatin Capsules contain Isotretinoin, providing an effective solution for severe forms of acne

Dosage adjustments may be necessary since Oratane’s therapeutic response and adverse events vary between patients

A cumulative treatment dose of 120-150mg/kg has been shown to increase remission rates and prevent relapse.

Patients with renal impairment should start at lower doses, and Oratane is contraindicated during pregnancy and breastfeeding.

This article covers absorption, distribution, metabolism, elimination, teratogenicity, and more to ensure a thorough understanding of Oratane’s use and effects

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Vendor: CRYSTOLITE
SKU: DER000000253
Availability: In Stock Pre order Out of stock
Description

ORATANE TABLETS : Your Guide to Acne Treatment with Isotretinoin

Composition:

  • ORATANE TABLETS 10mg Soft
    Gelatin Capsules: Each capsule contains Isotretinoin
  • ORATANE TABLETS 20mg Soft
    Gelatin Capsules: Each capsule contains Isotretinoin

Therapeutic Indications:

Oratane is prescribed for severe acne, including nodular
conglobate acne and cases at risk of permanent scarring that haven't responded
to standard treatments

Dosage and Administration:

  • Begin with 0.5mg/kg
    daily
  • Doses typically range
    from 0.51.0mg/kg per day
  • Higher doses (up to
    2.0mg/kg) may be needed for severe or truncal acne
  • Take capsules with
    food once or twice daily
  • A cumulative dose of
    120150mg/kg over the treatment period is often effective
  • Duration varies by
    daily dose and individual response but is typically 1624 weeks
  • Treatment may
    continue at lower doses for longer duration in case of intolerance

Special Dosage Instructions:

  • Patients with renal
    impairment should start with a lower dose and increase gradually
  • Oratane is
    contraindicated in pregnant or breastfeeding women
  • Pediatric patients
    under 12 years old should not use Oratane

Undesirable Effects:

  • Dryness of the skin,
    lips, and mucous membranes
  • Skin disorders such
    as exanthema, pruritis, and facial erythema
  • Musculoskeletal
    issues like myalgia and arthralgia

Behavioral disorders
and central nervous system effects

  • Enhanced skin
    sensitivity to sunlight
  • Hair thinning and
    reversible alopecia
  • Acne flare may occur
    at the start but usually subsides within 710 days

Absorption, Distribution, Metabolism, and Elimination:

  • Absorption of
    Isotretinoin from the gastrointestinal tract varies
  • Taking Isotretinoin
    with food doubles its bioavailability
  • Concentrations of
    Isotretinoin in the epidermis are lower than in serum
  • Major metabolites
    include 4oxoisotretinoin and tretinoin
  • Elimination halflife
    for unaltered drug is about 19 hours

Termination of
Oratane therapy leads to endogenous retinoid concentrations within two weeks

Teratogeicity:

Isotretinoin has
shown teratogenic potential in animal studies

It has therapeutic
implications for women of childbearing age and is contraindicated in pregnant
individuals

Presentation:

Oratane Soft Gelatin Capsules are available in blister packs
of 30 capsules

This comprehensive guide provides crucial information about
Oratane Soft Gelatin Capsules and their use in treating severe acne with
Isotretinoin. Always consult with your healthcare provider for personalized
treatment recommendations

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