ORATANE TABLETS : Your Guide to Acne Treatment with Isotretinoin

Composition:

• ORATANE TABLETS 10mg Soft
  Gelatin Capsules: Each capsule contains Isotretinoin
• ORATANE TABLETS 20mg Soft
  Gelatin Capsules: Each capsule contains Isotretinoin

Therapeutic Indications:

Oratane is prescribed for severe acne, including nodular
conglobate acne and cases at risk of permanent scarring that haven’t responded
to standard treatments

Dosage and Administration:

•  Begin with 0.5mg/kg
  daily
•  Doses typically range
  from 0.51.0mg/kg per day
•  Higher doses (up to
  2.0mg/kg) may be needed for severe or truncal acne
•  Take capsules with
  food once or twice daily
•  A cumulative dose of
  120150mg/kg over the treatment period is often effective
•  Duration varies by
  daily dose and individual response but is typically 1624 weeks
•  Treatment may
  continue at lower doses for longer duration in case of intolerance

Special Dosage Instructions:

•  Patients with renal
  impairment should start with a lower dose and increase gradually
•  Oratane is
  contraindicated in pregnant or breastfeeding women
•  Pediatric patients
  under 12 years old should not use Oratane

Undesirable Effects:

•  Dryness of the skin,
  lips, and mucous membranes
•  Skin disorders such
  as exanthema, pruritis, and facial erythema
•  Musculoskeletal
  issues like myalgia and arthralgia

Behavioral disorders
and central nervous system effects

•  Enhanced skin
  sensitivity to sunlight
•  Hair thinning and
  reversible alopecia
•  Acne flare may occur
  at the start but usually subsides within 710 days

Absorption, Distribution, Metabolism, and Elimination:

•  Absorption of
  Isotretinoin from the gastrointestinal tract varies
•  Taking Isotretinoin
  with food doubles its bioavailability
•  Concentrations of
  Isotretinoin in the epidermis are lower than in serum
•  Major metabolites
  include 4oxoisotretinoin and tretinoin
•  Elimination halflife
  for unaltered drug is about 19 hours

Termination of
Oratane therapy leads to endogenous retinoid concentrations within two weeks

Teratogeicity:

 Isotretinoin has
shown teratogenic potential in animal studies

 It has therapeutic
implications for women of childbearing age and is contraindicated in pregnant
individuals

Presentation:

Oratane Soft Gelatin Capsules are available in blister packs
of 30 capsules

This comprehensive guide provides crucial information about
Oratane Soft Gelatin Capsules and their use in treating severe acne with
Isotretinoin. Always consult with your healthcare provider for personalized
treatment recommendations