ORATANE TABLETS (ISOTRETIOIN) 20mg PACK OF 30 SOFT GELATIN CAPSULES
₨ 2,995
ORATANE TABLETS (Isotretinoin, soft gelatin capsule, 20mg by crystolite, Each Pack Contains 30 Capsules)
Oratane Soft Gelatin Capsules contain Isotretinoin, providing an effective solution for severe forms of acne
Dosage adjustments may be necessary since Oratane’s therapeutic response and adverse events vary between patients
A cumulative treatment dose of 120-150mg/kg has been shown to increase remission rates and prevent relapse.
Patients with renal impairment should start at lower doses, and Oratane is contraindicated during pregnancy and breastfeeding.
This article covers absorption, distribution, metabolism, elimination, teratogenicity, and more to ensure a thorough understanding of Oratane’s use and effects
ORATANE TABLETS : Your Guide to Acne Treatment with Isotretinoin
Composition:
- ORATANE TABLETS 10mg Soft
Gelatin Capsules: Each capsule contains Isotretinoin - ORATANE TABLETS 20mg Soft
Gelatin Capsules: Each capsule contains Isotretinoin
Therapeutic Indications:
Oratane is prescribed for severe acne, including nodular
conglobate acne and cases at risk of permanent scarring that haven’t responded
to standard treatments
Dosage and Administration:
- Â Begin with 0.5mg/kg
daily - Â Doses typically range
from 0.51.0mg/kg per day - Â Higher doses (up to
2.0mg/kg) may be needed for severe or truncal acne - Â Take capsules with
food once or twice daily - Â A cumulative dose of
120150mg/kg over the treatment period is often effective - Â Duration varies by
daily dose and individual response but is typically 1624 weeks - Â Treatment may
continue at lower doses for longer duration in case of intolerance
Special Dosage Instructions:
- Â Patients with renal
impairment should start with a lower dose and increase gradually - Â Oratane is
contraindicated in pregnant or breastfeeding women - Â Pediatric patients
under 12 years old should not use Oratane
Undesirable Effects:
- Â Dryness of the skin,
lips, and mucous membranes - Â Skin disorders such
as exanthema, pruritis, and facial erythema - Â Musculoskeletal
issues like myalgia and arthralgia
Behavioral disorders
and central nervous system effects
- Â Enhanced skin
sensitivity to sunlight - Â Hair thinning and
reversible alopecia - Â Acne flare may occur
at the start but usually subsides within 710 days
Absorption, Distribution, Metabolism, and Elimination:
- Â Absorption of
Isotretinoin from the gastrointestinal tract varies - Â Taking Isotretinoin
with food doubles its bioavailability - Â Concentrations of
Isotretinoin in the epidermis are lower than in serum - Â Major metabolites
include 4oxoisotretinoin and tretinoin - Â Elimination halflife
for unaltered drug is about 19 hours
Termination of
Oratane therapy leads to endogenous retinoid concentrations within two weeks
Teratogeicity:
 Isotretinoin has
shown teratogenic potential in animal studies
 It has therapeutic
implications for women of childbearing age and is contraindicated in pregnant
individuals
Presentation:
Oratane Soft Gelatin Capsules are available in blister packs
of 30 capsules
This comprehensive guide provides crucial information about
Oratane Soft Gelatin Capsules and their use in treating severe acne with
Isotretinoin. Always consult with your healthcare provider for personalized
treatment recommendations
| Brand |
|---|
Brand
crystolite
CRYSTOLITE
Embrace a radiant and luminous complexion with CRYSTOLITE, a trusted brand now available at derma.pk. CRYSTOLITE offers a range of high-quality skincare products formulated to brighten, hydrate, and revitalize your skin, leaving it looking and feeling its best.oratane
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