Terbiderm Cream (Terbinafine Tablets USP) ?Oral Antifungal Agent

Composition:

• TERBIDERM cream
• Terbiderm Forte Tablets
• Each tablet contains Terbinafine 250mg (as Terbinafine HCI BP)

Properties:

• ?Broadspectrum antifungal activity
• ?Fungicidal and fungistatic effects
• ?Targets dermatophytes, molds, and dimorphic fungi
• ?Interferes with fungal sterol biosynthesis
• ?Inhibits squalene epoxidase in fungal cell membrane
• ?Concentrates in skin, hair, and nails

Pharmacokinetics:

• ?Peak plasma concentrations achieved within 2 hours
• ?Moderately affected by food
• ?Strong binding to plasma proteins (99%)
• ?Rapid diffusion through the dermis and stratum corneum
• ?Secreted in sebum, achieving high concentrations in hair follicles
• ?Distributed into the nail plate in the first few weeks of therapy
• ?Eliminated through urine

Indications:

• ?Fungal infections of the skin, hair, and nails
• ?Dermatophytes (Trichophyton, Microsporum, Epidermophyton)
• ?Candida skin infections
• ?Onychomycosis (fungal nail infection)
• ?Not effective for pityriasis versicolor
• Dosage and Administration:
• ?Dosage varies by age group and indication
• ?Duration of treatment varies by the severity of the infection
• ?Best results when taken with meals
• ?Specific regimens for tinea corporis, cruris, pedis, cutaneous candidiasis, hair and scalp infections, and onychomycosis

Contraindications:

?Hypersensitivity to terbinafine

Precautions:

• ?Use with caution in patients with chronic liver dysfunction or impaired renal function
• ?Pregnancy: Use only if potential benefits outweigh risks
• ?Terbinafine is excreted in breast milk; avoid breastfeeding during oral treatment

Interactions:

• ?Negligible impact on drugs metabolized via the cytochrome P450 system
• ?Possible menstrual irregularities when used with oral contraceptives
• ?May be accelerated by drugs inducing metabolism or inhibited by drugs inhibiting cytochrome P450

Side Effects:

• ?Mild to moderate and transient
• ?Common side effects include gastrointestinal symptoms and nonserious skin reactions
• ?Rare cases of serious skin reactions, taste disturbances, and hepatobiliary dysfunction
• ?Isolated cases of hematological disorders (neutropenia, thrombocytopenia)

Overdosage:

• ?Rare, with reported cases of nausea, epigastric pain, and dizziness
• ?Treatment includes activated charcoal and symptomatic support

Terbiderm cream ?Facts:

• ?Terbinafine is a fastacting antifungal for skin and nail infections
• ?High cure rates (over 90%) for dermatophyte infections
• ?Most effective in treating fungal nail infections within 3 to 6 months
• ?Regimen duration depends on the type and severity of infection
• ?Take terbinafine with meals for best results

• Follow your doctor’s advice for a healthier, infectionfree life Terbiderm is your solution for fungal skin and nail infections