Terbiderm Cream (Terbinafine Tablets USP) Oral Antifungal Agent

Composition:

• TERBIDERM cream
• Terbiderm Forte Tablets
• Each tablet contains Terbinafine 250mg (as Terbinafine HCI BP)

Properties:

• Broadspectrum antifungal activity
• Fungicidal and fungistatic effects
• Targets dermatophytes, molds, and dimorphic fungi
• Interferes with fungal sterol biosynthesis
• Inhibits squalene epoxidase in fungal cell membrane
• Concentrates in skin, hair, and nails

Pharmacokinetics:

• Peak plasma concentrations achieved within 2 hours
• Moderately affected by food
• Strong binding to plasma proteins (99%)
• Rapid diffusion through the dermis and stratum corneum
• Secreted in sebum, achieving high concentrations in hair follicles
• Distributed into the nail plate in the first few weeks of therapy
• Eliminated through urine

Indications:

• Fungal infections of the skin, hair, and nails
• Dermatophytes (Trichophyton, Microsporum, Epidermophyton)
• Candida skin infections
• Onychomycosis (fungal nail infection)
• Not effective for pityriasis versicolor
• Dosage and Administration:
• Dosage varies by age group and indication
• Duration of treatment varies by the severity of the infection
• Best results when taken with meals
• Specific regimens for tinea corporis, cruris, pedis, cutaneous candidiasis, hair and scalp infections, and onychomycosis

Contraindications:

Hypersensitivity to terbinafine

Precautions:

• Use with caution in patients with chronic liver dysfunction or impaired renal function
• Pregnancy: Use only if potential benefits outweigh risks
• Terbinafine is excreted in breast milk; avoid breastfeeding during oral treatment

Interactions:

• Negligible impact on drugs metabolized via the cytochrome P450 system
• Possible menstrual irregularities when used with oral contraceptives
• May be accelerated by drugs inducing metabolism or inhibited by drugs inhibiting cytochrome P450

Side Effects:

• Mild to moderate and transient
• Common side effects include gastrointestinal symptoms and nonserious skin reactions
• Rare cases of serious skin reactions, taste disturbances, and hepatobiliary dysfunction
• Isolated cases of hematological disorders (neutropenia, thrombocytopenia)

Overdosage:

• Rare, with reported cases of nausea, epigastric pain, and dizziness
• Treatment includes activated charcoal and symptomatic support

Terbiderm cream Facts:

• Terbinafine is a fastacting antifungal for skin and nail infections
• High cure rates (over 90%) for dermatophyte infections
• Most effective in treating fungal nail infections within 3 to 6 months
• Regimen duration depends on the type and severity of infection
• Take terbinafine with meals for best results

• Follow your doctor's advice for a healthier, infectionfree life Terbiderm is your solution for fungal skin and nail infections