TRETIDERM Gel: Effective Acne Treatment with Isotretinoin

 Composition:

TRETIDERM Gel contains Isotretinoin at a concentration of 006% w/w

 Pharmacological Properties:

Isotretinoin, structurally related to Vitamin A, plays a key role in regulating epithelial cell growth and differentiation The exact mechanism of action of isotretinoin is still under investigation, but when used
systemically, it effectively suppresses sebaceous gland activity, reduces sebum production, combats Propionibacterium acnes, and alleviates inflammation.

In topical applications, it behaves similarly to tretinoin, stimulating epidermal mitosis, promoting desquamation, and preventing the formation of acne lesions.

 Indications:

TRETIDERM Gel is recommended for the topical treatment of acne vulgaris It effectively targets both inflammatory and noninflammatory lesions

 Directions For Use:

Apply TRETIDERM Gel sparingly over the entire affected area once or twice daily Ensure the skin is clean and dry before application Patients should be aware that it may take 68 weeks of consistent use to observe
therapeutic effects

 Contraindications:

TRETIDERM Gel should not be used by individuals with a known hypersensitivity to any of its ingredients

 Use During Pregnancy and Lactation:

The safety of topically applied isotretinoin during human pregnancy remains inadequately studied. Systemic use of isotretinoin has shown teratogenic effects in humans, making it inadvisable for use during pregnancy.

Although percutaneous absorption of isotretinoin from TRETIDERM Gel is minimal, there’s uncertainty regarding its excretion during lactation, so its use should be avoided while nursing

 Adverse Effects:

Typically, TRETIDERM Gel may cause mild stinging, burning, or irritation, and may lead to localized redness and peeling These reactions usually resolve when treatment is temporarily discontinued. If irritation persists or becomes severe, discontinue treatment and consult a healthcare professional

 Precautions:

•  Avoid applying
  TRETIDERM Gel to mucous membranes, the lips, mouth, eyes, or the angles of the nose
•  Use caution when applying the gel to sensitive skin areas, like the neck
•  Do not use on broken, eczematous, or sunburned skin
•  Protect treated areas from sunlight; if exposure is unavoidable, use sunscreen or cover the areas with clothing
•  Avoid using sunlamps during TRETIDERM treatment

 Although tretinoin has not been found to cause irritation or promote carcinogenesis in humans, it has been linked to an acceleration in UVB radiation induced cutaneous tumors in hairless mice Individuals with a personal or family history of cutaneous epithelioma should exercise caution

 Drug Interactions:

Use caution when combining TRETIDERM with other topical acne treatments Particular care should be taken with products containing peeling agents (eg, benzoyl peroxide) or abrasive cleansers

 Storage Conditions:

Store TRETIDERM Gel below 25 °C, protecting it from heat, light, and moisture Keep it out of the reach of children

 Presentation:

TRETIDERM Gel is available in 10gm tubes, making it a convenient option for topical acne treatment