Makazi (Azithromycin): Treating Bacterial Infections

 Composition:

MAKAZI CAPSULES 250mg Capsules:
Each capsule contains Azithromycin (as dihydrate) equivalent to 250mg
Azithromycin

 Description:

MAKAZI CAPSULES is a semisynthetic antibiotic belonging to the
azalide group It’s an antibacterial agent that inhibits protein synthesis,
classified under the antibiotics pharmacological group The molecular weight of
Azithromycin is 78500

 Pharmacodynamic Properties:

Azithromycin is a macrolide antibiotic that inhibits
bacterial protein synthesis by binding to the ribosomal 50s subunit and
inhibiting peptide translocation It concentrates in phagocytes and contributes
to drug distribution in inflamed tissues

 Microbiological Coverage:

Makazi is effective against various bacteria, including
Staphylococcus aureus, Staphylococcus pneumoniae, Herophilus influenzae,
Neisseria gonorrhoeae, Chlamydia pneumonia, and more It’s important to note
that some bacterial strains may be resistant to Azithromycin

 Therapeutic Indications:

Makazi is prescribed for the treatment of:

•  Acute bacterial
  sinusitis
•  Community acquired
  pneumonia
•  Pharyngitis/tonsillitis
•  Uncomplicated skin
  and skin structure infections
•  Genital ulcer
  diseases in men
•  Acute bacterial
  exacerbations of chronic obstructive pulmonary disease

 Dosage and Method of Administration:

Makazi should be taken at least 1 hour before or 2 hours
after a meal The dosage varies based on the condition and its severity

 Precautions:

•  Makazi is not
  recommended in patients with severe liver disease or hypersensitivity to
  Azithromycin
•  Caution is advised in
  patients with renal impairment, and it should not be used in patients with
  severe renal dysfunction
•  It should be used
  with caution in patients at risk for prolonged cardiac repolarization
•  The drug should only
  be used when necessary during pregnancy or lactation

 Interactions:

Azithromycin may interact with various drugs, including
aluminum based antacids, cyclosporine, digoxin, and more Consult a healthcare provider
for potential interactions

 Side Effects:

Common side effects include gastrointestinal symptoms like
diarrhea, nausea, abdominal pain, and vomiting Less frequently, it may cause
allergic reactions, cardiovascular issues, nervous system problems, skin
reactions, and more

 Overdose:

Symptoms of overdose may include reversible hearing loss,
severe nausea, vomiting, and diarrhea Treatment involves administration of
medicinal charcoal and symptomatic support

 Storage Conditions:

Store below 30°C, protect from sunlight and moisture, and
keep out of reach of children

 How Supplied:

Makazi is available in capsule and tablet forms in packs of
10