VORCAZ: Your Guide to Voriconazole Tablets

VORCAZ TABLET (Voriconazole), a powerful antifungal medication, is available in two strengths: 50mg and 200mg in the form of Vorcaz tablets. This article will provide you with a comprehensive overview of Voriconazole tablets, including their composition, clinical pharmacology, indications, contraindications, and dosage recommendations

Composition and Description

Each filmcoated Vorcaz tablet contains either 50mg or 200mg of Voriconazole, a triazole antifungal agent. Its chemical formula is C16H14F3N5O, and it has a molecular weight of 349.3

Clinical Pharmacology

Pharmacodynamics: Voriconazole belongs to the antimycotics pharmacotherapeutic group, with triazole derivatives. This medication combats fungal infections systemically.

Pharmacokinetics: Voriconazole’s pharmacokinetics are characterized by rapid and consistent absorption, accumulation, and nonlinear metabolism. Its metabolism saturates, leading to a greater than proportional increase in exposure with higher doses. The drug is primarily eliminated through hepatic metabolism, with minimal urinary excretion

 Indications and Usage

Voriconazole gets to work against a variety of fungal infections, tackling invasive aspergillosis head-on, clearing out candidemia in non-neutropenic patients, winning against fluconazole-resistant serious invasive Candida infections, and even taking down infections caused by Scedosporium spp. and Fusarium spp. This medication combats fungal infections systemically.

Contraindications

Do not give voriconazole to people who are allergic to it or any of its inactive ingredients.

Drug Interactions

Voriconazole can interact with various drugs, affecting their plasma concentrations. Efavirenz doses at 400 mg or higher are no-go with this drug, as it dramatically lowers plasma efavirenz levels.

Adverse Reactions

The most common adverse reactions associated with Voriconazole include visual impairment, pyrexia, rash, vomiting, nausea, diarrhea, headache, peripheral edema, abnormal liver function tests, respiratory distress, and abdominal pain. These reactions are generally mild to moderate

Dosage and Administration

The dosing of Voriconazole requires a specific loading dose regimen to achieve steady state plasma concentrations on the first day of treatment. We can adjust the maintenance dose based on your clinical response.  Detailed dosage recommendations are available for both adults and children