VORCAZ TABLET (VORICONAZOLE) 200 mg PACK OF 10 TABLETS
VORCAZ TABLETS (Voriconazole) Tablets J.P 200mg, Product by Daneen Pharma
VORCAZ tablets contain Voriconazole, a broad-spectrum antifungal agent
They are indicated for treating invasive aspergillosis and candidaemia in non-neutropenic patients
Voriconazole has nonlinear pharmacokinetics and should be dosed carefully
Contraindications include hypersensitivity and coadministration with certain drugs
Common side effects include visual impairment, pyrexia, and gastrointestinal symptoms

VORCAZ: Your Guide to Voriconazole Tablets
VORCAZ TABLET (Voriconazole), a powerful antifungal medication, is available in two strengths: 50mg and 200mg in the form of Vorcaz tablets. This article will provide you with a comprehensive overview of Voriconazole tablets, including their composition, clinical pharmacology, indications, contraindications, and dosage recommendations
Composition and Description
Each filmcoated Vorcaz tablet contains either 50mg or 200mg of Voriconazole, a triazole antifungal agent. Its chemical formula is C16H14F3N5O, and it has a molecular weight of 349.3
Clinical Pharmacology
Pharmacodynamics: Voriconazole belongs to the antimycotics pharmacotherapeutic group, with triazole derivatives. This medication combats fungal infections systemically.
Pharmacokinetics: Voriconazole's pharmacokinetics are characterized by rapid and consistent absorption, accumulation, and nonlinear metabolism. Its metabolism saturates, leading to a greater than proportional increase in exposure with higher doses. The drug is primarily eliminated through hepatic metabolism, with minimal urinary excretion
Indications and Usage
Voriconazole gets to work against a variety of fungal infections, tackling invasive aspergillosis head-on, clearing out candidemia in non-neutropenic patients, winning against fluconazole-resistant serious invasive Candida infections, and even taking down infections caused by Scedosporium spp. and Fusarium spp. This medication combats fungal infections systemically.
Contraindications
Do not give voriconazole to people who are allergic to it or any of its inactive ingredients.
Drug Interactions
Voriconazole can interact with various drugs, affecting their plasma concentrations. Efavirenz doses at 400 mg or higher are no-go with this drug, as it dramatically lowers plasma efavirenz levels.
Adverse Reactions
The most common adverse reactions associated with Voriconazole include visual impairment, pyrexia, rash, vomiting, nausea, diarrhea, headache, peripheral edema, abnormal liver function tests, respiratory distress, and abdominal pain. These reactions are generally mild to moderate
Dosage and Administration
The dosing of Voriconazole requires a specific loading dose regimen to achieve steady state plasma concentrations on the first day of treatment. We can adjust the maintenance dose based on your clinical response. Detailed dosage recommendations are available for both adults and children
Usage and Benefits of Vorcaz Tablet
- Effective Antifungal Treatment: Vorcaz is a broad-spectrum antifungal agent, making it effective against a variety of fungi, including those resistant to other treatments like fluconazole-resistant Candida infections.
- Versatile Indications: It is used to treat invasive aspergillosis, serious Candida infections, and fungal infections caused by Fusarium and Scedosporium species.
- Targeted Action: Vorcaz selectively inhibits fungal sterol biosynthesis, disrupting cell membrane integrity and effectively killing fungal cells.
- Well-Tolerated: Vorcaz is generally well-tolerated, with most side effects being mild to moderate, including visual disturbances and gastrointestinal issues.
- Convenient Administration: Vorcaz tablets are taken orally, typically once or twice daily, making it easier for patients to adhere to the treatment regimen.
How to Use Vorcaz Tablet
Follow these instructions for proper use of Vorcaz Tablets:
- Start with the loading dose to rapidly achieve therapeutic plasma concentrations. For adults, this typically includes 200mg every 12 hours on the first day.
- After the loading dose, the maintenance dose is usually 200mg once or twice daily depending on the clinical response.
- Swallow the tablets whole with a glass of water, preferably on an empty stomach for optimal absorption. You can take them with or without food, but consistency is key.
- For pediatric patients or those with renal/hepatic impairments, consult with a healthcare provider for specific dosing adjustments.
Always follow the dosage prescribed by your doctor, and consult them if you experience any adverse effects or unusual symptoms.
1. What is Vorcaz used for?
Vorcaz (Voriconazole) is an antifungal medication used to treat a variety of serious fungal infections, including invasive aspergillosis, candidemia in non-neutropenic patients, and infections caused by fungi such as Fusarium spp. and Scedosporium spp.
2. How does Vorcaz work?
Vorcaz works by inhibiting fungal cell membrane synthesis through its action on the enzyme lanosterol 14α-demethylase, which is essential for the production of ergosterol, a key component of the fungal cell membrane. This disrupts the membrane, leading to cell death.
3. What is the recommended dosage of Vorcaz?
The dosing regimen of Vorcaz includes an initial loading dose followed by a maintenance dose based on clinical response. Typically, the starting dose is higher to quickly reach steady-state plasma concentrations. Your healthcare provider will provide specific dosage recommendations based on your condition.
4. What are the common side effects of Vorcaz?
Common side effects of Vorcaz include visual disturbances (such as blurred vision), rash, fever, nausea, vomiting, headache, diarrhea, and liver enzyme abnormalities. Most side effects are mild to moderate, but you should inform your doctor if symptoms worsen.
5. Can Vorcaz be used during pregnancy or breastfeeding?
Voriconazole is classified as pregnancy category D, meaning it may cause harm to the fetus. It is not recommended during pregnancy unless the benefits outweigh the risks. It is also excreted in breast milk, so it should be avoided while breastfeeding unless absolutely necessary.
