TERBIN-DS TABLET 250mg (TERBINAFINE) PACK OF 10 TABLETS
TERBIN-DS TABLETS (Terbinafine HCI BP. Eq. To Terbinafine 250mg, Broad Spectrum Antifungal, A Product of Martin Dow) Each Pak Contains 10 Tablets
Terbin and Terbin DS tablets are potent antifungal medications effective against various fungal infections, including nail and skin conditions
Terbinafine interferes with fungal sterol biosynthesis, leading to the death of fungal cells. It is fungicidal against dermatophytes and molds
These tablets are indicated for onychomycosis, a common fungal nail infection, providing an effective solution for this challenging condition
In general, Terbin is well tolerated, with common side effects such as skin reactions and gastrointestinal symptoms. Serious adverse effects are rare
Terbin should be used cautiously in patients with liver or kidney issues, and close monitoring is recommended. Pregnant and breastfeeding women should avoid its use
TERBIN (TERBINAFINE) 250mg DS Tablets: A Comprehensive Guide
TERBIN-DS TABLET (terbinafine) are allylamines with
broad-spectrum antifungal properties. Terbinafine's chemical name is N(6,6dimethyl2hepten4inyl)Nmethyl1naphthalene
methylamine, with a molecular mass of 327.90
Composition:
-
Terbin Tablets: Each
tablet contains Terbinafine HCl (BP.) equivalent to Terbinafine -
TERBIN-DS TABLET:
Each tablet contains Terbinafine HCl (BP.) equivalent to Terbinafine
Therapeutic Indications:
Terbin and Terbin DS tablets are indicated for the treatment
of:
- Tinea capitis
- Onychomycosis (fungal nail infection) caused by
dermatophyte fungi - Fungal skin infections, including tinea corporis, tinea
cruris, tinea pedis, and yeast infections caused by Candida (e.g., Candida
Albicans) when oral therapy is appropriate - Note: Oral terbinafine is not effective for Pityriasis
versicolor
Clinical Pharmacology:
- Mechanism of Action:
Terbinafine is fungicidal against dermatophytes, molds, and certain dimorphic
fungi. Its activity against yeasts can be fungicidal or fungistatic, depending
on the species - Pharmacodynamics:
Terbinafine interferes with fungal sterol biosynthesis, leading to fungal cell
death - Absorption:
Terbinafine is well absorbed (approximately 70%), with a bioavailability of
about 50%. Peak plasma concentration is reached about 1.5 hours after a single
250 mg dose - Distribution:
Terbinafine accumulates rapidly in skin, hair, and nails, achieving levels
associated with fungicidal activity - Metabolism and
Excretion: Terbinafine is metabolized by the liver, excreted mainly in urine
(80%), and in feces (20%)
Drug Interactions:
- Cimetidine: Decreases
terbinafine clearance - Fluconazole:
Increases terbinafine Cmax and AUC - Ketoconazole and
Amiodarone: May increase terbinafine exposure - Rifampicin: Increases
terbinafine clearance - Caffeine: Terbinafine
decreases caffeine clearance - Desipramine:
Terbinafine decreases desipramine clearance - Ciclosporin:
Terbinafine increases ciclosporin clearance
Warnings and Precautions:
- Hepatic: Use with
caution in patients with hepatic conditions; monitor liver function - Renal: Use with
caution in patients with impaired renal function - Skin: Serious skin
reactions may occur rarely - Ophthalmologic:
Changes in the ocular lens and retina may occur - Immune: Monitor
complete blood count in patients with known or suspected immunodeficiency - Hematologic: Rare
cases of blood dyscrasias have been reported - Neurologic and
Senses: Disturbances in visual, auditory, and tactile senses may occur - Psychiatric: Anxiety
and depressive symptoms may occur
Special Population:
- Pregnancy: Avoid oral
terbinafine use during pregnancy - Nursing Mothers:
Terbinafine is excreted in breast milk; avoid breastfeeding during treatment - Geriatrics: Use with
caution in elderly patients
Overdosage:
Symptoms of overdosage may include headache, nausea,
epigastric pain, and dizziness. Treatment involves drug elimination, activated
charcoal administration, and symptomatic supportive therapy
Adverse Effects:
Common adverse effects include skin reactions,
gastrointestinal symptoms, headache, fatigue, and taste disturbances. Uncommon
effects may include paresthesia, while rare effects involve hepatobiliary
reactions, blood dyscrasias, and more
Stability:
Check the expiry date on the packaging
Packs:
Terbin is available in the following forms:
- Tablets 125mg (10's)
- DS Tablets 250mg
(10's)
Instructions:
- Keep all medicines
out of the reach of children - Store below 30 °C,
protected from light, heat, and moisture - Dispensed only on prescription
by a registered medical practitioner
Usage and Benefits of TERBIN 250mg DS Tablets
- Effective Treatment for Fungal Infections: TERBIN provides potent treatment for a range of fungal infections, including nail fungus (onychomycosis) and skin infections like athlete's foot, jock itch, and ringworm.
- Fungicidal Action: TERBIN’s fungicidal properties target and kill the fungi, offering faster and more reliable results compared to fungistatic treatments.
- Broad-Spectrum Activity: It is effective against various fungal species, including dermatophytes, molds, and some yeasts, making it a versatile antifungal agent.
- Well-Tolerated by Most Patients: Most patients tolerate TERBIN well with minimal side effects when taken as prescribed.
- Simple Dosage: With a once-daily dosage, TERBIN is easy to incorporate into your treatment plan for consistent results.
How to Use TERBIN 250mg DS Tablets
Follow these guidelines for the correct usage of TERBIN 250mg DS Tablets:
- Take one 250mg tablet orally once daily with or without food, as directed by your healthcare provider.
- For fungal nail infections (onychomycosis), treatment may last up to 6 weeks. For skin infections like tinea, the typical duration is 2 to 4 weeks.
- Ensure you take the full course of treatment, even if symptoms improve before completing the prescribed duration.
- If you miss a dose, take it as soon as you remember, but do not double the dose to compensate for a missed one.
Always follow your doctor’s prescribed instructions for the best results.
1. What is TERBIN used for?
TERBIN (Terbinafine) is an oral antifungal medication used to treat various fungal infections such as onychomycosis (fungal nail infection), tinea capitis (scalp infections), and other dermatophyte infections including tinea corporis, tinea cruris, tinea pedis, and yeast infections like Candida albicans.
2. How does TERBIN work?
Terbinafine works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. This interference leads to fungal cell death, making Terbin a fungicidal agent effective against dermatophytes, molds, and certain yeasts.
3. What is the recommended dosage for TERBIN Tablets?
The typical dosage for TERBIN tablets is 250mg once daily for adults. For onychomycosis (fungal nail infections), treatment may last up to 6 weeks, while for other skin infections like tinea, the duration may range from 2 to 4 weeks. Always follow your healthcare provider’s prescribed dosage and treatment duration.
4. What are the side effects of TERBIN Tablets?
Common side effects include gastrointestinal disturbances (nausea, abdominal pain), headaches, fatigue, and taste disturbances. Rare side effects may include hepatobiliary reactions, blood dyscrasias, and visual disturbances. If you experience unusual symptoms, contact your healthcare provider immediately.
5. Can TERBIN be used during pregnancy or breastfeeding?
Terbinafine should be avoided during pregnancy as it may pose risks to the fetus. It is also excreted in breast milk, so it should not be used while breastfeeding. Always consult your doctor before using Terbin if you are pregnant or breastfeeding.