• Adapalene 0.1% (standard USP strength): Third-generation retinoid with well-established efficacy and improved tolerability vs first-generation retinoids • Normalises follicular keratinisation: Prevents microcomedone formation — the underlying cause of all acne lesion types (comedones, papules, pustules) • Selective RAR binding: Binds nuclear retinoic acid receptors specifically, modulating cell differentiation and inflammation without cytosolic receptor binding — less irritating than tretinoin • Anti-inflammatory: Inhibits inflammatory cascade mediators, reducing redness and papule/pustule severity • Suitable entry-level retinoid for first-time retinoid users or patients with sensitive skin (vs 0.3% Forte) • Once-nightly application; clinical improvement typically seen from 8–12 weeks

As directed by your dermatologist. 1. Wash face gently with a mild, non-abrasive cleanser and pat dry. 2. Apply a thin film of Adapco Gel to acne-affected skin areas once daily at night. 3. Avoid the eye area, lips, nostrils, and mucous membranes. 4. Do not apply to cuts, abrasions, eczematous, or sunburned skin. 5. Apply SPF 30+ broad-spectrum sunscreen every morning — adapalene increases photosensitivity. 6. Avoid waxing on adapalene-treated skin. 7. If no improvement after 12 weeks, consult your dermatologist for re-evaluation. 8. Do not store above 30°C. Protect from light and heat. Keep out of reach of children. 9. For external use only.

Q: Does Adapco Gel require a prescription? A: Yes. Adapco Gel contains Adapalene, a topical retinoid, and is a prescription-only medicine. Always use under dermatologist supervision. Q: What is the difference between Adapco Gel (0.1%) and Adapco Forte Gel (0.3%)? A: Adapco Gel is the standard 0.1% strength — the first-line option for most acne patients and those new to retinoids. Adapco Forte at 0.3% is prescribed for moderate-to-severe acne or when 0.1% proves insufficient. Your dermatologist will advise the right strength. Q: How long does Adapco Gel take to show results? A: Expect gradual improvement over 8–12 weeks of consistent nightly use. An initial purging phase (temporary increase in breakouts) in the first 2–4 weeks is common with retinoids. Q: Must I use sunscreen with Adapco Gel? A: Yes — essential. Adapalene increases skin photosensitivity. Use SPF 30+ broad-spectrum sunscreen every morning and avoid prolonged sun exposure. Q: Can Adapco Gel be used during pregnancy or breastfeeding? A: Adapalene is Pregnancy Category C. Safety in pregnancy is not established. Use with caution during breastfeeding. Consult your doctor. Q: What age group can use Adapco Gel? A: Indicated for patients aged 12 years and above. Not recommended for children under 12.