Amorin 50mg Tablets — Azathioprine Immunosuppressant
Amorin 50mg Tablets contain Azathioprine, a purine analogue immunosuppressant used to prevent organ transplant rejection and treat autoimmune diseases. Requires regular CBC and LFT monitoring. Critical interaction with allopurinol — reduce to 25% dose if combined. Specialist prescription required.
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Amorin 50mg Tablets — Azathioprine Immunosuppressant
Description
What is Amorin 50mg?
Amorin 50mg Tablets contain Azathioprine 50mg, a purine analogue immunosuppressant. It is converted in the body to 6-mercaptopurine (6-MP) and then to thiopurine nucleotides, which inhibit lymphocyte DNA synthesis — suppressing immune responses. Used to prevent organ rejection and to treat autoimmune diseases. Prescription required — specialist initiation and ongoing monitoring mandatory.
How Does Amorin Work?
Azathioprine is a pro-drug: it converts to 6-mercaptopurine and then to 6-thioguanine nucleotides (6-TGN). These block de novo purine synthesis and halt lymphocyte proliferation. The enzyme TPMT (thiopurine methyltransferase) metabolises 6-MP; patients with reduced TPMT activity accumulate toxic 6-TGN levels. TPMT testing before initiation is strongly recommended.
Uses of Amorin 50mg
Indications: organ transplant rejection prevention (kidney, liver, heart, lung — with other immunosuppressants), rheumatoid arthritis (disease-modifying), inflammatory bowel disease (Crohn's disease, ulcerative colitis), SLE, autoimmune hepatitis, myasthenia gravis. Prescription required — always under specialist supervision.
Dosage & Administration
Transplantation: 1–5 mg/kg/day induction; 1–3 mg/kg/day maintenance. Autoimmune conditions: 1–3 mg/kg/day. Take with food. Same time daily. Do not stop abruptly. If taking allopurinol, dose must be reduced to 25% (see Precautions). See our general medicines collection for related products.
Side Effects
Myelosuppression (Critical): leucopenia, thrombocytopenia, anaemia — CBC monitoring weekly for first month, then monthly. Report fever, unusual bruising or bleeding immediately. Hepatotoxicity: monitor LFTs regularly. Other: nausea, vomiting, diarrhoea, alopecia, increased infection risk (opportunistic infections), increased long-term malignancy risk (lymphoma — rare).
Precautions
Allopurinol interaction (Critical): Allopurinol inhibits xanthine oxidase — dramatically raises 6-MP levels. If combined, reduce azathioprine to 25% of normal dose with intensive CBC monitoring. TPMT deficiency: Patients with low TPMT accumulate toxic metabolite levels — test TPMT before starting. Infection screening: Screen for latent TB and hepatitis B before starting. Pregnancy Category D: contraindicated unless benefit clearly outweighs risk — teratogenic. Effective contraception required. Live vaccines contraindicated during therapy. This is a prescription-only specialist medicine. Visit our essential health products collection.
Frequently Asked Questions
Q: Why must I have blood tests with Amorin?
A: Azathioprine can suppress the bone marrow, reducing white cells, platelets and red cells. Regular CBC monitoring detects this early before serious complications occur.
Q: What is the allopurinol interaction with Azathioprine?
A: Allopurinol blocks xanthine oxidase, causing a 4-fold build-up of toxic 6-MP metabolites. If both must be used together, reduce azathioprine to 25% of the normal dose under strict specialist supervision.
Q: Is Amorin safe in pregnancy?
A: No. Azathioprine is Category D — avoid in pregnancy unless benefit clearly outweighs risk. Use effective contraception and consult your specialist.
Usage & Benefits
- Prevents rejection of transplanted kidneys, livers, hearts and lungs
- Treats autoimmune diseases: rheumatoid arthritis, IBD (Crohn's/UC), SLE, autoimmune hepatitis, myasthenia gravis
- Steroid-sparing agent — reduces dependence on long-term corticosteroids
- Well-established immunosuppressant with decades of clinical use
- Oral tablet formulation for convenient daily dosing
How To Use
Transplantation: 1–5 mg/kg/day (induction); 1–3 mg/kg/day (maintenance). Autoimmune conditions: 1–3 mg/kg/day as directed by specialist. Take with food to reduce nausea. Same time each day. Do not stop abruptly. CBC weekly for first month, then monthly. LFTs monitored regularly. If taking allopurinol: reduce azathioprine to 25% of normal dose — critical interaction. Prescription required — specialist supervision mandatory.
FAQs
Why must I have regular blood tests with Amorin?
Azathioprine can suppress bone marrow, reducing white blood cells, platelets and red cells. Weekly CBC for the first month, then monthly monitoring detects this early before serious complications occur.
What is the allopurinol interaction with Azathioprine?
Allopurinol blocks xanthine oxidase — the enzyme that breaks down 6-mercaptopurine from azathioprine — causing a 4-fold toxic metabolite build-up. If both must be used, reduce azathioprine to 25% of normal dose under strict specialist supervision.
Is Amorin (Azathioprine) safe in pregnancy?
No. Azathioprine is Category D (teratogenic) and should be avoided in pregnancy unless benefit clearly outweighs risk. Use effective contraception and consult your transplant or rheumatology specialist.
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