Vorcaz 200mg Tablets (Voriconazole) - Pack of 10
Vorcaz 200mg Tablets contain voriconazole, a broad-spectrum triazole antifungal that inhibits fungal cytochrome P450 14-alpha-lanosterol demethylase. Prescription required, hospital-initiated. Indicated for invasive aspergillosis, serious Fusarium and Scedosporium infections, candidemia in non-neutropenic patients and oesophageal candidiasis. Often used in immunocompromised patients under specialist guidance. Dosing follows a loading-dose then maintenance pattern with therapeutic drug monitoring where available. Voriconazole has non-linear pharmacokinetics and many drug interactions. Safety: hepatotoxicity, QT prolongation, visual disturbances, photosensitivity and skin cancer risk with long-term use. Use only under specialist supervision.
Pay in 3 Installments of
Rs.
771
Vorcaz 200mg Tablets (voriconazole) - Pack of 10
Description
VORCAZ: Your Guide to Voriconazole Tablets
VORCAZ TABLET (Voriconazole), a powerful antifungal medication, is available in two strengths: 50mg and 200mg in the form of Vorcaz tablets. This article will provide you with a comprehensive overview of Voriconazole tablets, including their composition, clinical pharmacology, indications, contraindications, and dosage recommendations
Composition and Description
Each filmcoated Vorcaz tablet contains either 50mg or 200mg of Voriconazole, a triazole antifungal agent. Its chemical formula is C16H14F3N5O, and it has a molecular weight of 349.3
Clinical Pharmacology
Pharmacodynamics: Voriconazole belongs to the antimycotics pharmacotherapeutic group, with triazole derivatives. This medication combats fungal infections systemically.
Pharmacokinetics: Voriconazole's pharmacokinetics are characterized by rapid and consistent absorption, accumulation, and nonlinear metabolism. Its metabolism saturates, leading to a greater than proportional increase in exposure with higher doses. The drug is primarily eliminated through hepatic metabolism, with minimal urinary excretion
Indications and Usage
Voriconazole gets to work against a variety of fungal infections, tackling invasive aspergillosis head-on, clearing out candidemia in non-neutropenic patients, winning against fluconazole-resistant serious invasive Candida infections, and even taking down infections caused by Scedosporium spp. and Fusarium spp. This medication combats fungal infections systemically.
Contraindications
Do not give voriconazole to people who are allergic to it or any of its inactive ingredients.
Drug Interactions
Voriconazole can interact with various drugs, affecting their plasma concentrations. Efavirenz doses at 400 mg or higher are no-go with this drug, as it dramatically lowers plasma efavirenz levels.
Adverse Reactions
The most common adverse reactions associated with Voriconazole include visual impairment, pyrexia, rash, vomiting, nausea, diarrhea, headache, peripheral edema, abnormal liver function tests, respiratory distress, and abdominal pain. These reactions are generally mild to moderate
Dosage and Administration
The dosing of Voriconazole requires a specific loading dose regimen to achieve steady state plasma concentrations on the first day of treatment. We can adjust the maintenance dose based on your clinical response. Detailed dosage recommendations are available for both adults and children
Usage & Benefits
Key Benefits
- Broad-spectrum triazole effective against Aspergillus species, many Candida species, Fusarium and Scedosporium
- First-line oral therapy for invasive aspergillosis in many guidelines
- Active against some fluconazole-resistant Candida species
- Oral 200mg tablet allows step-down from intravenous voriconazole in eligible patients
- Penetrates well into lungs, brain and other tissues for treatment of deep-seated mycoses
- Authentic prescription antifungal by Daneen Pharma, supplied via derma.pk under specialist supervision
How To Use
How to Use
1. Use only on a hospital or specialist prescription with appropriate monitoring.
2. Adults are usually loaded with 400mg every 12 hours for 2 doses (or 6mg/kg IV), then maintained on 200mg every 12 hours.
3. Dose may be increased to 300mg every 12 hours if response is inadequate, or reduced for toxicity - your doctor will guide this.
4. Take the tablets at least one hour before, or one hour after, a meal for best absorption.
5. Continue therapy for the duration directed by your specialist - this is often weeks to months.
Tell your doctor all medicines you take - voriconazole has many CYP-mediated drug interactions. Avoid sun exposure and wear high-SPF sunscreen because of severe photosensitivity and skin cancer risk. Report any visual disturbance, jaundice or palpitations immediately. Use in pregnancy only if essential.
FAQs
Is Vorcaz a routine antifungal?
No - voriconazole is a specialist prescription antifungal used for serious invasive fungal infections, usually started in hospital.
Why is sun protection important?
Voriconazole causes severe photosensitivity and can increase the risk of skin cancer with long-term use. Wear high-SPF sunscreen and protective clothing.
I see flashes or blurred vision - is that normal?
Visual disturbances (blurred vision, photopsia, colour changes) are common in the first weeks and usually reversible. Tell your doctor and avoid driving if affected.
Are there important drug interactions?
Yes - voriconazole interacts with many medicines (warfarin, certain statins, immunosuppressants, antiepileptics, antiretrovirals). Tell your doctor and pharmacist everything you take.
Can I take Vorcaz in pregnancy?
Voriconazole can harm the fetus. Use only if there is no safer alternative and discuss contraception with your doctor while on treatment.
Dermatologist Recommended
Healer's Pharma Minoxidil 5% + Finasteride 0.25% Hair Regrowth Spray
0.25% Finasteride Topical Hair Loss Spray by Healer's Pharma
