CONFLU CAPSULE 150mg PACK OF 1 CAPSULE
CONFLU CAPSULE (Fluconazole, 150mg, Your Solution for Fungal Infections – Safe, Effective, and Convenient)
CONFLU contains Fluconazole, a potent antifungal drug that combats various fungal infections, including Candida and dermatophytes
With peak concentrations reached within 1 to 2 hours of oral administration, CONFLU quickly gets to work to combat fungal infections
CONFLU is effective against a range of fungi, making it a versatile choice for treating various fungal infections
With a high bioavailability and the ability to reach various bodily fluids, CONFLU ensures widespread coverage to tackle fungal infections effectively
Available in easy-to-use capsules, CONFLU simplifies the administration of antifungal treatment
CONFLU (Fluconazole) Capsules: Your Guide to Antifungal Medication
CONFLU CAPSULE presents Fluconazole in form for oral use, available in 150mg strength.
What's Inside?
Each CONFLU capsule contains 150mg of Fluconazole.
Antimicrobial Action:
CONFLU's active ingredient, Fluconazole, is a triazole antifungal drug that effectively inhibits fungi. It does so by impairing cytochrome P450-dependent enzymes, leading to the disruption of ergosterol synthesis in fungal cell membranes. CONFLU targets a range of fungal species, including Blastomeres dermatitis, Candida spp, Coccidiosis's imcites, Cryptococcus neoformans, Epidermophyton spp, Histoplasma capsulatum, Micros Porum spp, and Trichophyton spp.
Pharmacokinetics:
Fluconazole reaches peak concentrations 1 to 2 hours after oral administration.
It undergoes effective absorption through oral administration, exhibiting a bioavailability of approximately 90%. The drug is distributed widely in the body, with a volume of distribution equal to the total body water.
Fluconazole is secreted in various bodily fluids like saliva, breast milk, sputum, vaginal fluids, and peritoneal fluids.
The concentration of Fluconazole in the cerebrospinal fluid is around 50% to 90% of the plasma concentration.
The body eliminates approximately 80% of the drug through urine in its unchanged form, while metabolites account for the remaining 10%.
The drug's elimination half-life is approximately 30 hours, which may increase with renal impairment.
Indications:
CONFLU is primarily used to treat various fungal infections, including systemic candidiasis, superficial mucosal candidiasis (e.g., oropharyngeal, pharyngeal, and vaginal), and fungal skin infections. It has also shown promise in cases of coccidioidomycosis, cryptococcosis, blastomycosis, chromoblastomycosis, histoplasmosis.
Adverse Effects:
Common side effects of CONFLU include gastrointestinal issues and taste disturbances. Other less common effects encompass headaches, dizziness, leukopenia, thrombocytopenia, hyperlipidemia, and elevated liver enzymes. Notably, severe hepatotoxicity and Stevens-Johnson syndrome have been reported in patients with AIDS, along with rare occurrences of anaphylaxis and angioedema.
Fertility, Pregnancy, and Lactation:
In animal studies, Fluconazole did not affect the fertility of male or female rats.
During pregnancy, the use of Fluconazole in the first trimester may pose a slight increase in the risk of spontaneous abortion, although this is not conclusively established.
Fluconazole passes into breast milk but remains at concentrations lower than in the mother's plasma. Therefore, breastfeeding is discouraged after repeated or high-dose use of Fluconazole.
Uses in Children:
Doctors generally do not recommend using Fluconazole in children under 16. However, if doctors deem treatment essential, they recommend specific dosages for different infections in children aged 1 year and older.
Interactions:
CONFLU may interact with various drugs, such as Rifampicin, Hydrochlorothiazide, and other medications, affecting their plasma concentrations and potentially causing cardiac arrhythmias. Additionally, Fluconazole may impact the metabolism of different drugs through enzyme inhibition, leading to potential drug interactions.
Precautions:
Use CONFLU cautiously in patients with hepatic and renal insufficiency. Doctors do not recommend using it during pregnancy due to potential teratogenic effects observed in animal studies.
Packing:
CONFLU is available in blister packs, with each pack containing a single capsule (1's).
Usage and Benefits of CONFLU (Fluconazole) Capsules
Usage
CONFLU (Fluconazole) is used to treat a variety of fungal infections, including systemic candidiasis, mucosal candidiasis, and fungal skin infections. It is an oral antifungal medication that provides effective relief and helps in preventing the recurrence of fungal infections.
Benefits
- Broad-Spectrum Antifungal: CONFLU targets a wide range of fungal species, including Candida spp., Cryptococcus neoformans, and Histoplasma capsulatum, making it highly effective for systemic and superficial infections.
- Effective for Mucosal Infections: It is particularly useful in treating infections like oral thrush, vaginal yeast infections, and esophageal candidiasis.
- Convenient Oral Formulation: CONFLU is available in an easy-to-take oral capsule form, making it convenient for long-term treatment.
- Well Absorbed: Fluconazole has a high bioavailability (approximately 90%) and is widely distributed in the body, ensuring effective treatment for infections in different organs.
- Prevents Recurrence: When used as prescribed, Fluconazole helps reduce the risk of recurrent fungal infections, especially in immunocompromised patients.
How to Use CONFLU (Fluconazole) Capsules
Follow these guidelines for the proper use of CONFLU capsules:
- Doctor's Instructions: Always follow the dosage and administration instructions provided by your healthcare provider.
- Oral Administration: Take CONFLU capsules orally with or without food, as directed by your doctor.
- Consistency: Take the capsule at the same time each day to maintain consistent blood levels of Fluconazole.
- Missed Dose: If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at the same time.
- Duration: The duration of treatment depends on the type of infection. Always complete the full course as prescribed by your doctor.
If you accidentally ingest more than the prescribed dose, seek medical attention immediately.
Frequently Asked Questions
1. What is CONFLU (Fluconazole) used for?
CONFLU (Fluconazole) is used to treat a wide range of fungal infections, including systemic candidiasis, superficial mucosal candidiasis (such as oropharyngeal, pharyngeal, and vaginal candidiasis), and fungal skin infections. It is also effective in treating coccidioidomycosis, cryptococcosis, blastomycosis, chromoblastomycosis, and histoplasmosis.
2. How does CONFLU (Fluconazole) work?
Fluconazole works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. It impairs cytochrome P450-dependent enzymes, which leads to the disruption of fungal cell membranes, ultimately causing the death of the fungi. CONFLU targets a variety of fungal species, including Candida spp., Cryptococcus neoformans, and Histoplasma capsulatum.
3. What are the common side effects of CONFLU (Fluconazole)?
Common side effects of CONFLU include gastrointestinal issues, taste disturbances, headaches, dizziness, leukopenia, thrombocytopenia, hyperlipidemia, and elevated liver enzymes. In rare cases, severe reactions such as hepatotoxicity, Stevens-Johnson syndrome, and anaphylaxis have been observed, particularly in patients with AIDS.
4. Can CONFLU be used during pregnancy or breastfeeding?
Fluconazole should be used with caution during pregnancy, especially in the first trimester, due to potential risks. It may slightly increase the risk of spontaneous abortion, but this has not been conclusively proven. Fluconazole passes into breast milk, so it is advised to avoid breastfeeding after repeated or high-dose use of Fluconazole.
5. What are the interactions of CONFLU (Fluconazole) with other drugs?
CONFLU may interact with medications such as Rifampicin, Hydrochlorothiazide, and others. These interactions can alter plasma concentrations and may lead to cardiac arrhythmias. Fluconazole can also inhibit enzymes responsible for drug metabolism, causing potential drug interactions. Always inform your doctor of any other medications you are taking.