Acevit-K27 Capsules
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Description
What is Acevit-K27?
Acevit-K27 Capsules are a triple-combination bone health supplement containing Calcium, Vitamin D3, and Vitamin K2-7 (Menaquinone-7 — the MK-7 form of K2). This combination addresses the three key steps of bone mineralisation in a single capsule. Available OTC at Derma.pk.
How Does Acevit-K27 Work?
Each ingredient plays a specific, synergistic role: Calcium is the primary structural mineral of bone matrix. Vitamin D3 promotes intestinal calcium absorption and renal calcium reabsorption, raising serum calcium for bone deposition. Vitamin K2-7 (Menaquinone-7) activates osteocalcin (the bone-specific protein that binds calcium into the hydroxyapatite matrix) and activates Matrix Gla Protein (MGP) which prevents calcium deposition in arterial walls and soft tissues. Without K2-7, supplemented calcium may deposit in arteries rather than bones — the triple combination ensures calcium goes where it is needed.
Uses of Acevit-K27
Used for: osteoporosis prevention and treatment; osteomalacia; hypocalcaemia; post-menopausal bone loss; prevention of rickets; and as a nutritional supplement for adults with inadequate dietary calcium and vitamin D. Particularly recommended for elderly patients, post-menopausal women, and individuals with low sun exposure.
Dosage & Administration
Take as directed by your doctor or pharmacist, typically one capsule once or twice daily with meals. Consult your healthcare provider for dosage based on your calcium deficiency status and existing medications. Avoid exceeding recommended doses to prevent hypercalcaemia.
Side Effects
Generally well tolerated. Mild: nausea, constipation, abdominal discomfort (take with food to minimise). Rare: hypercalcaemia with excessive doses (symptoms: polyuria, nausea, fatigue, confusion). Do not exceed recommended dose.
Precautions
Inform your doctor of all medicines — calcium supplements can interact with bisphosphonates, fluoroquinolone antibiotics, and thyroid medications (space dosing by 2–4 hours). Caution in patients with renal stones or hypercalcaemia. Vitamin D toxicity is possible with excessive supplementation. The MK-7 form of K2 has anticoagulant-modifying effects — patients on warfarin should consult their doctor before starting K2 supplementation.
Frequently Asked Questions
Q: Why is Vitamin K2-7 important in a calcium supplement?
A: K2-7 (Menaquinone-7) activates osteocalcin and Matrix Gla Protein, directing calcium into bones while preventing it from depositing in blood vessels — reducing vascular calcification risk associated with calcium-only supplementation.
Q: Who should take Acevit-K27?
A: Post-menopausal women, elderly adults, individuals with osteoporosis or low bone density, those with inadequate sun exposure (vitamin D deficiency), and patients on corticosteroid therapy causing bone loss.
Q: Does the MK-7 form of K2 interact with warfarin?
A: Yes — Vitamin K2 can affect warfarin anticoagulation. If you are on warfarin or other blood thinners, consult your doctor before starting Acevit-K27.
Usage & Benefits
- Triple synergy: Calcium provides bone mineral; D3 enhances intestinal absorption; K2-7 directs calcium into bones
- Vitamin K2-7 (MK-7) activates osteocalcin for superior bone matrix mineralisation
- Matrix Gla Protein activation by K2-7 prevents arterial and soft tissue calcification
- Supports prevention and treatment of osteoporosis, osteomalacia, and rickets
- Recommended for post-menopausal women, elderly adults, and low-sun-exposure individuals
- MK-7 form of K2 has longer half-life and better bone activation than MK-4
How To Use
Take Acevit-K27 Capsules as directed by your doctor or pharmacist.
Typically one capsule once or twice daily with a meal for best absorption.
Take at the same time each day for consistent results.
Avoid exceeding the recommended dose to prevent hypercalcaemia.
If taking other medications (bisphosphonates, thyroid drugs, fluoroquinolones), space them by 2 to 4 hours.
Patients on warfarin must consult their doctor before starting due to K2 interactions.
FAQs
Why is Vitamin K2-7 important in a calcium supplement?
K2-7 (Menaquinone-7) activates osteocalcin and Matrix Gla Protein. This directs calcium into bones and prevents it from depositing in blood vessel walls — reducing the vascular calcification risk associated with calcium supplementation alone.
Who should take Acevit-K27?
Post-menopausal women, elderly adults, people with osteoporosis or low bone density, individuals with limited sun exposure (vitamin D deficiency), and patients on corticosteroids causing bone loss.
Does K2-7 interact with warfarin?
Yes — Vitamin K2 can affect warfarin anticoagulation control. If you are on warfarin or other blood thinners, consult your doctor before starting Acevit-K27.
