Amdipine 5mg Tablets — Amlodipine Besylate
Amdipine 5mg Tablets contain Amlodipine Besylate, a dihydropyridine calcium channel blocker for hypertension and angina. 5mg is the standard starting dose; once-daily dosing with long half-life (35–50 hours). Well-tolerated in elderly patients. Prescription required.
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Amdipine 5mg Tablets — Amlodipine Besylate
Description
What is Amdipine 5mg?
Amdipine 5mg Tablets contain Amlodipine Besylate, a dihydropyridine calcium channel blocker (CCB) used for the management of hypertension (high blood pressure) and stable and variant (Prinzmetal) angina. Amlodipine has a long half-life of 35–50 hours, making once-daily dosing effective with gradual, sustained blood pressure reduction and minimal reflex tachycardia. 5mg is the standard starting dose for most patients. Prescription required.
How Does Amdipine Work?
Amlodipine selectively inhibits L-type calcium channels in vascular smooth muscle, reducing calcium entry and causing peripheral arterial vasodilation. This decreases peripheral vascular resistance (afterload), lowers blood pressure, and improves coronary artery blood flow — relieving myocardial ischaemia and anginal symptoms without significantly depressing heart rate or myocardial contractility.
Uses of Amdipine 5mg
Indicated for: essential hypertension (monotherapy or in combination), chronic stable angina, variant angina. Suitable for elderly patients and those with mild-to-moderate renal impairment. Used alongside ACE inhibitors, ARBs, or diuretics in combination antihypertensive regimens. Consult your doctor — prescription required.
Dosage & Administration
Adults: Starting dose 5mg once daily. If needed, may be titrated to 10mg once daily after 7–14 days under medical supervision. Take at the same time each day with or without food. Do not stop abruptly. For a full range of anti-hypertensive medicines in Pakistan, visit our collection.
Side Effects
Common: peripheral oedema (ankle swelling — most frequent CCB side effect, dose-dependent), headache, flushing, dizziness, fatigue. Less common: nausea, palpitations, somnolence. Rare: gingival hyperplasia, hepatitis. Oedema is caused by arteriolar dilation (not fluid overload) and may not respond to diuretics; dose reduction or agent switch may help.
Precautions
Caution in: severe hepatic impairment (use lower dose; half-life prolonged), hypotension, severe aortic stenosis. Generally well-tolerated in elderly and renal impairment. Avoid grapefruit juice (CYP3A4 inhibition raises amlodipine levels). Drug interactions: simvastatin (co-administration with amlodipine limits simvastatin to 20 mg/day), cyclosporine, tacrolimus. Pregnancy: generally avoided. This is a prescription-only medicine. Browse our general medicines collection for cardiovascular products.
Frequently Asked Questions
Q: Should I start with Amdipine 5mg or 10mg?
A: 5mg is the standard starting dose for most adults. Your doctor will assess after 1–2 weeks and titrate to 10mg if the blood pressure target is not reached.
Q: Is Amdipine 5mg safe for elderly patients?
A: Yes. Amlodipine is generally well-tolerated in elderly patients, though the starting dose of 5mg is recommended and should not be exceeded without medical guidance.
Q: How long does it take for Amdipine to lower blood pressure?
A: Amlodipine begins to lower blood pressure within 24–48 hours; full therapeutic effect is typically seen after 7–14 days of regular use.
Usage & Benefits
- Lowers blood pressure via peripheral arterial vasodilation
- Relieves stable and variant (Prinzmetal) angina by improving coronary blood flow
- Once-daily dosing for consistent 24-hour blood pressure control
- Well-tolerated in elderly patients and those with renal impairment
- Minimal effect on heart rate (less reflex tachycardia vs. other CCBs)
- Can be used as monotherapy or combined with ACE inhibitors, ARBs or diuretics
How To Use
Adults: 5mg once daily. Titrate to 10mg after 7–14 days if blood pressure target not achieved. Take at the same time each day, with or without food. Swallow whole — do not crush or chew. Do not stop without consulting your doctor. Regular blood pressure monitoring recommended. Prescription required.
FAQs
Should I start with Amdipine 5mg or 10mg?
5mg is the standard starting dose for most adults. Your doctor will reassess after 1–2 weeks and titrate to 10mg if needed.
How long does it take for Amdipine 5mg to work?
Amlodipine begins to lower blood pressure within 24–48 hours; full therapeutic effect is usually seen after 7–14 days of regular use.
Is Amdipine 5mg safe for the elderly?
Yes. Amlodipine 5mg is generally well-tolerated in elderly patients, though hepatic impairment may require caution — always under medical supervision.
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