Amodip-V Plus 5/160/12.5mg Tablets — Amlodipine + Valsartan + HCTZ
Amodip-V Plus 5/160/12.5mg combines Amlodipine 5mg (CCB), Valsartan 160mg (ARB), and Hydrochlorothiazide 12.5mg (diuretic) for triple antihypertensive action. Lower Amlodipine dose variant — suitable when 10mg Amlodipine causes excessive ankle oedema. Prescription required.
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Amodip-v Plus 5/160/12.5mg Tablets — Amlodipine + Valsartan + Hctz
Description
What is Amodip-V Plus 5/160/12.5mg?
Amodip-V Plus Tablets 5/160/12.5mg contain a fixed-dose triple combination of Amlodipine 5mg (CCB), Valsartan 160mg (ARB), and Hydrochlorothiazide 12.5mg (thiazide diuretic). This triple-action antihypertensive is used for patients with hypertension not adequately controlled on dual CCB+ARB therapy, where adding a diuretic is appropriate but a lower Amlodipine dose is preferred. Prescription required; specialist oversight recommended.
How Does Amodip-V Plus Work?
Amlodipine 5mg blocks L-type calcium channels → arterial vasodilation → reduced peripheral vascular resistance. Valsartan 160mg blocks AT1 angiotensin II receptors → inhibits RAAS-mediated vasoconstriction and aldosterone secretion → lowers blood pressure and provides organ protection. Hydrochlorothiazide 12.5mg inhibits sodium-chloride co-transporter in the distal tubule → natriuresis and reduced plasma volume → additional blood pressure lowering. This synergistic three-pathway approach delivers comprehensive hypertension control.
Uses of Amodip-V Plus 5/160/12.5mg
Indicated for: hypertension uncontrolled on dual therapy in adults already stabilised on individual components at equivalent doses. The 5mg Amlodipine variant is preferred when higher-dose CCB causes troublesome oedema. Reduces cardiovascular and renal event risk. Consult your cardiologist — prescription required.
Dosage & Administration
Adults: One tablet once daily with water, with or without food. Take at the same time each day. Regular monitoring of blood pressure, electrolytes (potassium, sodium), renal function, and uric acid is essential. Do not stop abruptly — may cause rebound hypertension. See our anti-hypertensive medicines for related products.
Side Effects
From Amlodipine 5mg: peripheral oedema (less than 10mg), headache, flushing, dizziness. From Valsartan: hyperkalaemia, dizziness, hypotension. From HCTZ: hypokalaemia, hyponatraemia, hyperuricaemia, glucose intolerance, photosensitivity, postural hypotension. Triple combination may increase electrolyte imbalance risk — regular blood tests are mandatory.
Precautions
Contraindicated: pregnancy (ARB + HCTZ both contraindicated in all trimesters), anuria, severe renal/hepatic impairment. Caution with: lithium (HCTZ increases lithium toxicity risk), NSAIDs, aliskiren in diabetes. Gout patients: HCTZ can precipitate acute gout attacks — discuss with doctor. Monitor electrolytes and renal function at baseline and during therapy. This is a prescription-only medicine. Visit our general medicines collection.
Frequently Asked Questions
Q: What is the difference between Amodip-V Plus 5/160/12.5 and 10/160/12.5mg?
A: The Amlodipine dose differs (5mg vs 10mg). The 5mg variant is used when 10mg amlodipine causes excessive ankle oedema but the BP still needs the diuretic third agent added.
Q: Does HCTZ cause low potassium in Amodip-V Plus?
A: HCTZ tends to lower potassium; Valsartan tends to raise it. The net effect on potassium is variable — regular monitoring is essential for all patients on this triple combination.
Q: Is Amodip-V Plus safe in elderly patients?
A: Triple therapy in elderly patients requires careful dose titration and close monitoring for postural hypotension, electrolyte imbalances, and renal function. Start low, monitor frequently.
Usage & Benefits
- Triple antihypertensive: CCB 5mg + ARB 160mg + thiazide diuretic 12.5mg
- Three independent BP-lowering mechanisms in one convenient tablet
- Lower Amlodipine dose (5mg) reduces ankle oedema vs. 10mg variant
- Full-dose Valsartan 160mg for RAAS blockade and organ protection
- HCTZ adds volume-depleting effect to enhance overall BP control
- Suitable step-up from Amodip-V 5/160mg when diuretic addition is needed
How To Use
Adults: One tablet (5/160/12.5mg) once daily with water, with or without food. Take at the same time each day. Swallow whole. Monitor blood pressure, electrolytes (potassium, sodium), renal function and uric acid at baseline and regularly during treatment. Prescription required — specialist supervision essential.
FAQs
What is the difference between Amodip-V Plus 5/160/12.5 and 10/160/12.5mg?
The Amlodipine dose differs (5mg vs 10mg). The 5mg variant is preferred when 10mg amlodipine causes troublesome ankle swelling but the diuretic is still needed for BP control.
Does HCTZ in Amodip-V Plus affect blood sugar?
Yes. HCTZ can impair glucose tolerance. Diabetic patients should monitor blood glucose more closely and discuss this metabolic risk with their doctor.
Is triple antihypertensive therapy safe for elderly patients?
Triple therapy in elderly patients requires careful initiation, close monitoring for postural hypotension and electrolyte imbalances, and regular renal function checks — always under specialist supervision.
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