What is Amodip-V 5mg/80mg?

Amodip-V Tablets 5mg/80mg contain a fixed-dose combination of Amlodipine 5mg (dihydropyridine calcium channel blocker) and Valsartan 80mg (angiotensin II receptor blocker — ARB). This is the lowest-strength presentation of Amodip-V, suitable as an initial dual-therapy option for patients transitioning from monotherapy who need two complementary antihypertensive mechanisms without high starting doses of either component. Prescription required.

How Does Amodip-V 5/80 Work?

Amlodipine blocks L-type calcium channels in arteriolar smooth muscle, reducing vascular tone and peripheral resistance, thereby lowering blood pressure. Valsartan 80mg blocks AT1 angiotensin II receptors, preventing vasoconstriction and aldosterone release via the RAAS pathway. At 80mg, Valsartan provides partial RAAS blockade that can be uptitrated as needed. Together they deliver dual-pathway blood pressure reduction with manageable tolerability.

Uses of Amodip-V 5mg/80mg

Indicated for: essential hypertension in adults who need combination therapy, especially as initial dual therapy at lower doses to assess tolerability before uptitration. Also suitable as a replacement when both components have been individually titrated to these doses. Reduces cardiovascular event risk. Consult your doctor — prescription required.

Dosage & Administration

Adults: One tablet once daily with water, with or without food. Take at the same time each day. Do not crush or chew. Blood pressure, renal function and electrolytes should be monitored regularly. If BP control is insufficient, your doctor may uptitrate to 5/160mg or 10/160mg. See our anti-hypertensive medicines collection.

Side Effects

Common: peripheral oedema (from amlodipine), headache, flushing, dizziness. Valsartan 80mg is generally well-tolerated. Less common: hyperkalaemia (monitor potassium), first-dose hypotension (especially with concurrent diuretics), upper respiratory infection, back pain. At 80mg Valsartan dose, hyperkalaemia risk is lower than at 160mg but still monitor in renal impairment.

Precautions

Contraindicated: pregnancy (all trimesters — ARB foetotoxic), bilateral renal artery stenosis, history of angioedema with ARB. Caution with: NSAIDs, potassium-sparing diuretics, aliskiren (in diabetes). Monitor blood pressure, renal function (creatinine, eGFR) and potassium. This is a prescription-only medicine. Visit our general medicines collection for more cardiovascular options.

Frequently Asked Questions

Q: Who is Amodip-V 5/80mg suitable for?
A: It is the starter dual-combination option, suitable for patients beginning combination CCB+ARB therapy at conservative doses, or those whose doctor has titrated both individual components to these strengths.

Q: Can I switch from Amodip-V 5/80mg to 5/160mg?
A: Yes, if blood pressure is not adequately controlled on 5/80mg, your doctor may increase to 5/160mg or 10/160mg based on your response and tolerability.

Q: Does Amodip-V 5/80 affect the kidneys?
A: Valsartan is renoprotective in hypertension but requires monitoring of kidney function and potassium levels, particularly in patients with chronic kidney disease or diabetes.