Amodip-V Tablets 5mg/160mg — Amlodipine + Valsartan
Amodip-V 5mg/160mg combines Amlodipine 5mg (CCB) and Valsartan 160mg (ARB) for dual-mechanism blood pressure control. Standard-dose Amlodipine with full-dose ARB — effective for patients needing dual antihypertensive therapy. Prescription required.
Pay in 3 Installments of
Rs.
172
Amodip-v Tablets 5mg/160mg — Amlodipine + Valsartan
Description
What is Amodip-V 5mg/160mg?
Amodip-V Tablets 5mg/160mg contain a fixed-dose combination of Amlodipine 5mg (dihydropyridine calcium channel blocker) and Valsartan 160mg (angiotensin II receptor blocker — ARB). This dual-mechanism antihypertensive is used for patients with hypertension not controlled on monotherapy. The 5mg/160mg strength provides full-dose Valsartan ARB activity with the standard starting dose of Amlodipine, suitable for patients whose dose is being optimised. Prescription required.
How Does Amodip-V Work?
Amlodipine blocks L-type voltage-gated calcium channels in arterial smooth muscle, causing vasodilation and lowering peripheral vascular resistance. Valsartan selectively blocks AT1 angiotensin II receptors, preventing the vasoconstrictive and aldosterone-stimulating effects of angiotensin II. The two mechanisms are complementary — CCB reduces arterial tone while ARB blocks the RAAS axis — producing synergistic blood pressure reduction and superior cardiovascular protection compared to either drug alone.
Uses of Amodip-V 5mg/160mg
Indicated for: essential hypertension in adults when dual therapy is required. Reduces risk of cardiovascular events, stroke, and hypertensive renal damage. Also useful as a step-up from Amlodipine 5mg monotherapy by adding full-dose Valsartan. Consult your doctor — prescription required.
Dosage & Administration
Adults: One tablet once daily with a full glass of water, with or without food. Take at the same time each day. Do not crush or chew. Regular monitoring of blood pressure, renal function, and potassium is recommended. Browse our anti-hypertensive medicines for related products.
Side Effects
Common from Amlodipine component: peripheral oedema (ankle swelling), headache, flushing, dizziness. Common from Valsartan component: hyperkalaemia, dizziness, hypotension (first dose), upper respiratory tract infection. First-dose hypotension may occur — initiate in a supervised setting if hypovolaemic or on high-dose diuretics.
Precautions
Contraindicated: pregnancy (ARB foetotoxic), severe hepatic impairment, bilateral renal artery stenosis. Caution with: NSAIDs (reduce efficacy, increase renal risk), potassium-sparing diuretics (hyperkalaemia), aliskiren in diabetes. Monitor renal function and electrolytes periodically. This is a prescription-only medicine requiring specialist oversight. Visit our general medicines collection for more options.
Frequently Asked Questions
Q: What is the difference between Amodip-V 5/160mg and 10/160mg?
A: The Amlodipine dose differs (5mg vs 10mg); your doctor will choose based on your blood pressure response. Valsartan 160mg is the same in both. 5/160mg is typically used first; 10/160mg if more aggressive BP lowering is needed.
Q: Is Valsartan safe for kidney disease?
A: Valsartan is renoprotective in hypertensive patients and those with diabetic kidney disease, but requires careful monitoring of eGFR and potassium, especially at doses of 160mg.
Q: Can I take Amodip-V with other medicines?
A: Inform your doctor of all medications. Particular caution is needed with NSAIDs, diuretics, and potassium-sparing agents. Do not combine with another ARB or ACE inhibitor (dual RAAS blockade increases risk of hypotension and renal impairment).
Usage & Benefits
- Dual CCB+ARB therapy: Amlodipine vasodilation + Valsartan RAAS blockade
- Additive blood pressure reduction exceeding monotherapy
- Provides organ protection (cardiovascular and renal) via Valsartan 160mg
- Standard 5mg Amlodipine dose reduces ankle oedema compared to 10mg
- Once-daily dosing for round-the-clock BP control
- Step-up option from Amlodipine 5mg monotherapy with added full-dose ARB
How To Use
Adults: One tablet (5mg/160mg) once daily with water, with or without food. Take at the same time daily. Swallow whole. Monitor blood pressure, renal function and potassium periodically. Do not stop abruptly. Prescription required — take under specialist supervision.
FAQs
What is the difference between Amodip-V 5/160mg and 10/160mg?
The Amlodipine dose differs (5mg vs 10mg). 5/160mg is chosen when standard Amlodipine dose is preferred; 10/160mg when more aggressive BP lowering is needed. Valsartan 160mg is the same in both.
Can I combine Amodip-V 5/160mg with another ARB or ACE inhibitor?
No. Dual RAAS blockade (ARB + ACE inhibitor together) is not recommended due to increased risk of hypotension, hyperkalaemia, and renal impairment.
Is Valsartan safe for kidneys?
Valsartan 160mg is renoprotective in hypertension and diabetic nephropathy, but requires monitoring of eGFR and potassium.
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