Artem DS Plus 80/480mg Tab
Artem DS Plus 80/480mg Tab is the WHO gold-standard fixed-dose ACT containing Artemether 80mg and Lumefantrine 480mg for uncomplicated Plasmodium falciparum malaria in adults and children 35 kg+. Artemether acts within hours; lumefantrine clears residual parasites over 3 days — together they achieve high cure rates with low resistance. Prescription-only. Must be taken with food at every dose. Standard 6-dose regimen over 3 days.
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Artem Ds Plus 80/480mg Tab
Description
What is Artem DS Plus 80/480mg Tab?
Artem DS Plus 80/480mg Tab is a fixed-dose artemisinin-based combination therapy (ACT) containing Artemether 80mg and Lumefantrine 480mg — the WHO-recommended gold standard for uncomplicated Plasmodium falciparum malaria. It is a prescription-only antimalarial medicine.
How Does Artem DS Plus 80/480mg Work?
Artemether rapidly destroys the ring-stage malaria parasites within hours of administration. Lumefantrine provides a prolonged mopping-up effect, clearing residual parasites and preventing relapse. This dual mechanism targets the parasite at two different stages, significantly reducing treatment failure and resistance.
Uses of Artem DS Plus 80/480mg
First-line treatment for uncomplicated Plasmodium falciparum malaria in adults and children weighing 35 kg or more. Relieves malaria fever, chills, severe headache, fatigue, and muscle pain.
Dosage & Administration
Standard 6-dose regimen over 3 days: doses at 0, 8, 24, 36, 48, and 60 hours. Must be taken with food or a fat-containing meal at each dose — dietary fat approximately doubles lumefantrine bioavailability. Do not use in patients who cannot eat. Consult your prescribing physician for weight-based dosing in paediatric patients.
Side Effects
Common: headache, dizziness, nausea, anorexia, fatigue, arthralgia. Uncommon: QT-interval prolongation, palpitations, sleep disturbance. Artemether-lumefantrine should be avoided with other QT-prolonging drugs.
Precautions
Prescription required. Treatment only — not prophylaxis. Monitor ECG in cardiac patients. Avoid use in first trimester of pregnancy unless benefits outweigh risks. Not for severe or complicated malaria — hospitalisation and IV artesunate required for those cases.
Frequently Asked Questions
Q: What makes Artem DS Plus 80/480mg the preferred ACT?
A: The 80mg artemether + 480mg lumefantrine dose delivers optimal pharmacokinetics for adults, ensuring rapid parasite kill and sustained clearance with high cure rates.
Q: Why must it be taken with food?
A: Food (especially fatty food) roughly doubles the absorption of lumefantrine. Taking it on an empty stomach risks treatment failure.
Q: Is it safe in pregnancy?
A: Use only under medical supervision. Generally avoided in the first trimester; benefits vs risks must be assessed by a doctor in the second and third trimesters.
Usage & Benefits
- WHO-recommended gold-standard ACT for falciparum malaria
- Artemether 80mg provides rapid blood-stage parasite clearance
- Lumefantrine 480mg eliminates residual parasites and prevents relapse
- Dual mechanism significantly reduces treatment failure and drug resistance
- Relieves malaria fever, chills, fatigue, and muscle pain
- High efficacy in areas with artemether monotherapy resistance
How To Use
Take Artem DS Plus 80/480mg Tab exactly as prescribed by your doctor.
Must be taken WITH FOOD (fat-containing meal) at each of the 6 doses — fat doubles lumefantrine bioavailability.
Standard regimen: doses at hours 0, 8, 24, 36, 48, and 60 over 3 days.
Do not skip doses or stop early — complete the full course.
Consult your doctor for paediatric weight-based dosing below 35 kg.
FAQs
What makes Artem DS Plus 80/480mg the preferred ACT for adults?
The 80mg/480mg dose provides optimal pharmacokinetics for adults — ensuring sufficient artemether for rapid kill and adequate lumefantrine exposure for complete parasite clearance.
Why must each dose be taken with food?
Food (especially fatty food) approximately doubles lumefantrine absorption. Without food, plasma levels are too low for effective treatment.
Is this tablet safe during pregnancy?
Generally avoided in the first trimester. Use in second and third trimesters requires a doctor's assessment of benefits versus risks.
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