Avate: Dermatological Solution for Eczema and Psoriasis

Avate is a potent dermatological solution containing Methylprednisolone Aceponate (0.1% w/w), a synthetic corticosteroid. With its specialized formulation, Avate provides effective treatment for a variety of skin conditions, including eczema and psoriasis, in both adults and children.

Composition

• Active Ingredient: Methylprednisolone Aceponate (0.1% w/w)
• Form: Available as cream and ointment in a 10gm plastic tube

Description

Avate is a revolutionary white crystalline powder with solubility in methylene chloride, acetone, and ethyl acetate. Its molecular formula, C27H36O7, and molecular weight of 472.58 highlight its synthetic corticosteroid nature, making it highly effective for dermatological treatments.

Indications

Avate is designed to treat a variety of skin conditions, including:

• Eczema:
  • Endogenous eczema
  • Contact eczema
  • Vulgar eczema
  • Degenerative eczema
  • Dyshidrotic eczema
• Psoriasis: Suitable for adult and pediatric use

Pharmacological Action

Avate Cream works by binding to intracellular glucocorticoid receptors, delivering:

• Anti-inflammatory effects to reduce swelling and redness
• Antipruritic properties to alleviate itching
• Vasoconstrictive action to minimize blood vessel dilation and inflammation

Contraindications

Avate should not be used in the following conditions:

• Viral diseases (e.g., herpes, varicella)
• Tuberculous or syphilitic skin processes
• Post-vaccination skin reactions
• Rosacea, acne vulgaris, or perioral dermatitis when applied to the face
• Hypersensitivity: Avoid use if allergic to Methylprednisolone Aceponate

Adverse Reactions

Localized symptoms may include:

• Itching
• Burning
• Erythema

Rare effects:

• Atrophic skin changes with prolonged use

Dosage and Administration

• Application: Apply a thin layer of Avate once daily to affected areas.
• Duration:
  • Adults: Up to 12 weeks
  • Children: Up to 4 weeks

Precautions

• Avoid prolonged use: Especially in children, to prevent adrenal suppression.
• Prevent contact: Keep away from eyes, mouth, and mucous membranes.
• Infections: Discontinue use in spreading infections or hypersensitivity reactions.

Presentation

Avate is packaged in a 10gm plastic tube, offering convenience and precise application.

Conclusion

In summary, Avate provides a reliable solution for managing eczema and psoriasis with its anti-inflammatory, antipruritic, and vasoconstrictive properties. However, it is essential to carefully consider contraindications, adhere to recommended dosages, and monitor for potential adverse effects for safe and effective use. By following these guidelines, Avate can help restore healthy skin and improve quality of life.