What is Coversam 8mg/10mg?

Coversam Tablets 8mg/10mg are a prescription fixed-dose combination antihypertensive manufactured by Servier Pharma. Each tablet contains Perindopril Arginine 8mg (ACE inhibitor) and Amlodipine Besylate 10mg (dihydropyridine calcium channel blocker). This combination is indicated for patients with hypertension (high blood pressure) not adequately controlled with monotherapy, providing complementary dual-mechanism blood pressure lowering in a convenient single daily tablet. Prescription required — take only as directed by your doctor.

How Does Coversam 8mg/10mg Work?

Perindopril inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II — a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers systolic and diastolic blood pressure. Amlodipine blocks L-type voltage-gated calcium channels in arterial smooth muscle and cardiac tissue, causing vasodilation and reducing the afterload on the heart. The complementary mechanisms of ACE inhibition and calcium channel blockade provide additive blood pressure reduction with a more favourable side effect profile than higher doses of either drug alone. For related cardiovascular products, see our prescription medicines collection.

Uses of Coversam 8mg/10mg

Coversam 8mg/10mg is prescribed for: hypertension insufficiently controlled on perindopril 8mg or amlodipine 10mg monotherapy; patients already stable on perindopril and amlodipine as separate tablets (simplification therapy); and cardiovascular risk reduction in hypertensive patients with established coronary artery disease. Prescription required. For blood pressure monitoring equipment, visit our medical devices collection.

Dosage & Administration

Take one Coversam 8mg/10mg tablet once daily, at the same time each day, with or without food. Swallow whole with a glass of water. Do not crush or chew. Do not adjust the dose without consulting your cardiologist or physician. Regular blood pressure monitoring is essential during treatment. Do not stop the medication abruptly without medical guidance. Prescription required before dispensing.

Side Effects

Common side effects include peripheral oedema (ankle swelling from amlodipine), dry cough (ACE inhibitor class effect from perindopril), dizziness, flushing, and headache. Rarely, Perindopril can cause angioedema — seek emergency medical attention immediately if swelling of the face, lips, tongue, or throat occurs. Inform your doctor of any unusual symptoms.

Precautions

Contraindicated in pregnancy (angiotensin system drugs can harm the foetus — use effective contraception). Contraindicated in bilateral renal artery stenosis and a history of ACE inhibitor-induced angioedema. Use with caution in renal impairment — monitor serum creatinine and potassium. Avoid concurrent use of potassium-sparing diuretics or potassium supplements without monitoring. NSAIDs may reduce the antihypertensive effect. Keep out of reach of children. Store at room temperature.

Frequently Asked Questions

Q: Why is Coversam prescribed as a combination rather than separate tablets?
A: Fixed-dose combinations improve patient compliance, reduce pill burden, and provide complementary blood pressure lowering that is superior to titrating single agents to maximum dose.

Q: Can I stop taking Coversam if my blood pressure is normal?
A: No — hypertension is a chronic condition and blood pressure control with medication must be maintained. Never stop Coversam without consulting your doctor, as blood pressure may rebound.

Q: Is the dry cough from Coversam dangerous?
A: ACE inhibitor-induced dry cough is a class effect and is bothersome but not dangerous. If it significantly affects quality of life, your doctor may switch you to an ARB-based combination. Angioedema, however, is rare but serious — seek immediate help if facial or throat swelling occurs.