What is Dapa Met 5/850mg?

Dapa Met 5/850mg Tab 28s is a prescription combination anti-diabetic tablet containing Dapagliflozin 5mg and Metformin 850mg (immediate-release). It is used for the management of type 2 diabetes mellitus in adults who require dual glycaemic control through complementary mechanisms. The combination provides additive HbA1c reduction compared to either drug alone. Consult your doctor; prescription required.

How Does Dapa Met 5/850mg Work?

Dapagliflozin (SGLT-2 inhibitor) blocks glucose reabsorption in the proximal renal tubule, causing approximately 70–80g of glucose to be excreted in urine daily — an insulin-independent mechanism. This also produces a mild osmotic diuresis and natriuresis, with proven cardiovascular and renal benefits (DAPA-HF and DAPA-CKD trials). Metformin 850mg (biguanide) activates AMPK to suppress hepatic glucose production and improve peripheral insulin sensitivity. Together they deliver robust glycaemic control across multiple pathways.

Uses of Dapa Met 5/850mg

Dapa Met 5/850mg is indicated for adults with type 2 diabetes mellitus not adequately controlled on metformin alone, or as initial combination therapy when dual-agent treatment is appropriate. It is also beneficial in patients with type 2 diabetes and established cardiovascular disease or chronic kidney disease, given dapagliflozin's organ-protective properties. Not for type 1 diabetes.

Dosage & Administration

Take Dapa Met 5/850mg with meals to minimise metformin-associated gastrointestinal side effects (nausea, diarrhoea, abdominal cramps). Typical dosing is one tablet twice daily or as prescribed by your doctor. Swallow whole with a glass of water; do not crush, split, or chew. Drink adequate fluids daily — dapagliflozin causes mild urinary fluid loss. Renal function should be assessed before and periodically during treatment. Prescription required.

Side Effects

Dapagliflozin-related: urinary tract infections (UTIs), genital mycotic infections (thrush), osmotic diuresis (increased urination, thirst), hypotension, rare diabetic ketoacidosis (DKA — even with near-normal glucose; stop and seek emergency care if nausea, vomiting, fruity breath develop), rare Fournier's gangrene (necrotising fasciitis of perineum). Metformin-related: nausea, diarrhoea, metallic taste, abdominal discomfort — take with food; rare but serious lactic acidosis (contraindicated when eGFR <30 mL/min/1.73m²).

Precautions

Metformin: contraindicated in significant renal impairment (eGFR <30); caution when eGFR 30–45; hold 48 hours before and after iodinated contrast media. Dapagliflozin: hold during acute illness, surgery, or prolonged fasting (sick-day rule) to prevent DKA. Maintain genital hygiene to reduce mycotic infection risk. Avoid in type 1 diabetes. Monitor renal function, blood pressure, and signs of volume depletion regularly. Prescription required.

Frequently Asked Questions

Q: Why must Dapa Met 5/850mg be taken with food?
A: The metformin component commonly causes nausea, diarrhoea, and stomach discomfort on an empty stomach. Taking with a meal significantly reduces these side effects and improves tolerability.

Q: What is the difference between Dapa Met 5/850mg and Dapa Met 5/1000mg?
A: The only difference is the metformin dose — 850mg versus 1000mg. The dapagliflozin dose is the same (5mg). The 850mg formulation suits patients who tolerate lower metformin doses better.

Q: Should I stop dapagliflozin if I get sick or need surgery?
A: Yes — stop dapagliflozin during acute illness, major surgery, or prolonged fasting. This reduces the risk of euglycaemic diabetic ketoacidosis (DKA). Resume only when eating normally and under your doctor's guidance.