Domel Tablets 10mg – Domperidone for Nausea & Vomiting Relief
• Domel Tablets 10mg contain Domperidone, an Rx peripheral dopamine D2 receptor antagonist. • Treats nausea, vomiting, and gastroparesis (delayed gastric emptying) in adults. • Acts outside the blood-brain barrier — gastrokinetic antiemetic without central CNS sedation. • Prescription-only (Rx) in Pakistan — use the lowest effective dose for the shortest duration. • Available at Derma.pk with nationwide delivery across Pakistan.
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Domel Tablets 10mg – Domperidone for Nausea & Vomiting Relief
Description
Domel Tablets 10mg – Domperidone for Nausea & Vomiting Relief
Domel Tablets 10mg contain Domperidone 10mg, an Rx dopamine D2 receptor antagonist used for adults experiencing nausea, vomiting, and symptoms of gastroparesis (delayed gastric emptying). Domperidone acts peripherally on the chemoreceptor trigger zone (outside the blood-brain barrier), blocking the vomiting reflex without the central CNS side effects of older antiemetics. Its gastrokinetic action also accelerates gastric emptying and improves gastro-oesophageal motility, relieving bloating and postprandial discomfort.
- Rx antiemetic: blocks peripheral dopamine D2 receptors to stop vomiting reflex
- Gastrokinetic benefit: improves gastric emptying and reduces bloating
- Adults only — use the lowest effective dose for the shortest duration
- Caution: patients over 60, cardiac conduction abnormalities, or electrolyte disturbances
How to Use Domel Tablets 10mg
Take one tablet 15–30 minutes before meals as prescribed by your doctor. Swallow whole with water. Do not exceed the prescribed dose or duration. Monitor for headache, breast tenderness, or galactorrhoea and consult your doctor if these occur. Send prescription to sales@derma.pk or WhatsApp +92-320-5999650.
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Usage & Benefits
- Blocks peripheral dopamine D2 receptors in the chemoreceptor trigger zone to suppress nausea and vomiting reflex.
- Gastrokinetic action accelerates gastric emptying and improves gastro-oesophageal motility.
- Peripheral action minimises CNS side effects compared to older central dopamine antagonists.
- Relieves postprandial bloating, early satiety, and discomfort associated with gastroparesis.
- Prescription-regulated for safe, supervised antiemetic therapy.
How To Use
Take one tablet (10mg) 15–30 minutes before meals, up to three times daily, as prescribed by your doctor. Swallow whole with water. Use the lowest effective dose for the shortest duration. Caution in patients over 60 years, or those with cardiac conduction abnormalities or electrolyte disturbances. Report any breast tenderness, galactorrhoea, or irregular periods to your doctor.
FAQs
Why is Domperidone classified as Rx (prescription-only) in Pakistan?
Domperidone can prolong the cardiac QT interval at higher doses or in susceptible patients (elderly, cardiac disease, electrolyte disturbances). Medical oversight ensures appropriate patient selection and dose limitation.
How does Domperidone differ from Metoclopramide?
Both are dopamine antagonists and prokinetics. Domperidone acts peripherally (outside the blood-brain barrier), causing fewer CNS side effects like extrapyramidal reactions. Metoclopramide crosses the BBB and can cause sedation and tardive dyskinesia with prolonged use.
Can elderly patients use Domel Tablets safely?
Patients over 60 should use domperidone under close medical supervision and at the lowest effective dose, as they have a higher risk of cardiac arrhythmias and are more susceptible to QT prolongation.
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