Etrizine -L (Levocetirizine Dihydrochloride): Your Solution to Allergic Conditions

Description:

Etrizine-L tablets are the levoisomer of cetirizine (levocetirizine) with double the affinity for Hreceptors, offering rapid and long-lasting antihistaminic action compared to cetirizine

Composition:

Each film-coated tablet contains: Levocetirizine Dihydrochloride (M.S).5mg

Indications:

EtrizineL tablets are indicated in patients 6 years and above for the treatment of allergic conditions such as allergic rhinitis (seasonal and perennial), allergic conjunctivitis, and chronic idiopathic urticaria

Mode of Action:

EtrizineL is a potent, selective, peripheral H1 receptor antagonist with negligible effects on other receptors

Dosage:

• In adults and children older than 6 years: The recommended daily dose of Etrizine-L is 5mg
• In children aged 2 to 6 years: The recommended daily dose of Etrizine-L tablets is 2.5mg in two divided doses
• In patients with renal impairment: The dose should be adjusted according to creatinine clearance

Pharmacokinetics:

• Etrizine-L tablets reach peak plasma levels in approximately 1 hour
• They achieve steadystate plasma levels by the second day
• Etrizine-L tablets are extensively bound to blood components, with approximately 76% as the free fraction
• Poorly metabolized (14% of the total oral dose)

Pharmacodynamics:

• Double affinity for human H1 receptors compared to cetirizine
• No effect on the QT interval
• More effective in treating seasonal allergic rhinitis during prolonged pollen exposure compared to desloratadine
• Rapid onset of action (1 hour) and longer duration compared to desloratadine
• Superior in treating nasal congestion after the first dose

Contraindications:

• Hypersensitivity to the active ingredient or any of the inactive ingredients
• Glucosegalactose malabsorption, lactase deficiency, hereditary galactose intolerance
• Severe renal impairment

Side Effects:

Common side effects include redness, lack of concentration, somnolence, headache, agitation, dry mouth, constipation, and hypersensitivity reactions. These side effects are usually mild to moderate

Warnings:

• Avoid driving or operating machinery during treatment, as it may cause sedation
• Avoid excessive alcohol consumption during therapy

Precautions:

• After analyzing the risk and benefit, consider using it during pregnancy and breastfeeding.
• The safety of children under 6 years of age has not undergone evaluation for its safety.

Overdosing:

In cases of overdose, take symptomatic and supportive measures.

Storage:

Store below 30 °C, and protect from heat, light, and moisture.
Keep out of reach of children

Presentations:

Etrizine -L tablets 5mg: Blister pack of 10 Tablets

Etrizine-L offers relief from allergic conditions with its potent and long-lasting antihistaminic action. Consult your physician for proper dosage and guidance

Usage and Benefits of Etrizine-L

Etrizine-L is a highly effective antihistamine used for treating allergies. Here are its main benefits:

• Long-lasting relief: It provides prolonged relief from symptoms of allergic rhinitis, conjunctivitis, and chronic urticaria.
• Fast action: Etrizine-L has a rapid onset of action, typically starting to work within one hour of taking it.
• Low sedation: Compared to other antihistamines, it has a minimal sedating effect, making it suitable for daytime use.
• Safe for long-term use: Ideal for managing chronic allergies, especially for seasonal allergic rhinitis.

How to Use Etrizine-L

To use Etrizine-L effectively, follow the prescribed dosage:

• Adults and children over 6 years: Take one 5 mg tablet once a day.
• Children aged 2 to 6 years: Take 2.5 mg (half of a tablet) twice a day as recommended.

Ensure to follow your healthcare provider's instructions regarding the dosage, especially if you have renal impairment, as the dosage might need adjustment.

Frequently Asked Questions (FAQ) about Etrizine-L (Levocetirizine Dihydrochloride)

1. What is Etrizine-L and what conditions does it treat?

Etrizine-L is a medication that contains Levocetirizine Dihydrochloride, a potent antihistamine used to treat various allergic conditions. It is effective in treating allergic rhinitis (seasonal and perennial), allergic conjunctivitis, and chronic idiopathic urticaria (hives) in patients aged 6 years and above.

2. How does Etrizine-L work in the body?

Etrizine-L works by selectively blocking the H1 receptors, which are responsible for allergic reactions. By targeting these receptors, it prevents the release of histamine, a substance in the body that causes symptoms of allergies like itching, swelling, and inflammation. Its effects are potent and long-lasting, providing relief from allergy symptoms.

3. What is the recommended dosage for Etrizine-L?

The recommended daily dosage of Etrizine-L is:

• 5 mg for adults and children over 6 years old.
• 2.5 mg for children aged 2 to 6 years, in two divided doses.

If the patient has renal impairment, the dose may need to be adjusted by a healthcare provider based on creatinine clearance.

4. What are the possible side effects of Etrizine-L?

Common side effects of Etrizine-L include mild to moderate reactions such as:

• Redness
• Lack of concentration
• Somnolence (drowsiness)
• Headache
• Dry mouth
• Constipation
• Agitation

If any severe reactions like hypersensitivity occur, contact your healthcare provider immediately.

5. Are there any precautions or warnings I should know about?

Yes, Etrizine-L may cause sedation, so it's important to avoid driving or operating machinery while using it. Alcohol consumption should also be minimized during treatment. Pregnant and breastfeeding women should consult their doctor before using this medication. Children under 6 years of age have not been studied for safety.