Etrizine-L (Levocetirizine Dihydrochloride): Your Solution to Allergic Conditions

Etrizine-L by Derma Tecno is a levocetirizine antihistamine for allergic conditions, and is part of our Power Brands range.

Etrizine-L tablets are the levoisomer of cetirizine (levocetirizine) with double the affinity for H1 receptors, offering rapid and long-lasting antihistaminic action compared to cetirizine.

Composition

Each film-coated tablet contains: Levocetirizine Dihydrochloride (M.S) 5mg

Indications

Etrizine-L tablets are indicated in patients 6 years and above for the treatment of allergic conditions such as allergic rhinitis (seasonal and perennial), allergic conjunctivitis, and chronic idiopathic urticaria.

Mode of Action

Etrizine-L is a potent, selective, peripheral H1 receptor antagonist with negligible effects on other receptors.

Dosage

• In adults and children older than 6 years: The recommended daily dose of Etrizine-L is 5mg.
• In children aged 2 to 6 years: The recommended daily dose of Etrizine-L tablets is 2.5mg in two divided doses.
• In patients with renal impairment: The dose should be adjusted according to creatinine clearance.

Pharmacokinetics

• Etrizine-L tablets reach peak plasma levels in approximately 1 hour.
• They achieve steady-state plasma levels by the second day.
• Etrizine-L tablets are extensively bound to blood components, with approximately 76% as the free fraction.
• Poorly metabolized (14% of the total oral dose).

Pharmacodynamics

• Double affinity for human H1 receptors compared to cetirizine.
• No effect on the QT interval.
• More effective in treating seasonal allergic rhinitis during prolonged pollen exposure compared to desloratadine.
• Rapid onset of action (1 hour) and longer duration compared to desloratadine.
• Superior in treating nasal congestion after the first dose.

Contraindications

• Hypersensitivity to the active ingredient or any of the inactive ingredients.
• Glucose-galactose malabsorption, lactase deficiency, hereditary galactose intolerance.
• Severe renal impairment.

Side Effects

Common side effects include redness, lack of concentration, somnolence, headache, agitation, dry mouth, constipation, and hypersensitivity reactions. These side effects are usually mild to moderate.

Warnings

• Avoid driving or operating machinery during treatment, as it may cause sedation.
• Avoid excessive alcohol consumption during therapy.

Precautions

• After analyzing the risk and benefit, consider using it during pregnancy and breastfeeding.
• The safety of children under 6 years of age has not undergone evaluation for its safety.

Overdosing

In cases of overdose, take symptomatic and supportive measures.

Storage

Store below 30°C, and protect from heat, light, and moisture. Keep out of reach of children.

Presentations

Etrizine-L tablets 5mg: Blister pack of 10 Tablets

Etrizine-L offers relief from allergic conditions with its potent and long-lasting antihistaminic action. Consult your physician for proper dosage and guidance.