Glucovance 500/5mg Tablet 30s (Metformin + Glibenclamide)
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Description
Glucovance 500/5mg Tablet contains Metformin 500mg and Glibenclamide 5mg — a fixed-dose combination of a biguanide and a sulfonylurea antidiabetic agent at a higher Glibenclamide strength. It is indicated for the management of Type 2 diabetes mellitus. A valid prescription is required.
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Drug Information
- Active Ingredients: Metformin 500mg + Glibenclamide 5mg
- Drug Classes: Biguanide + Sulfonylurea (Antidiabetic Combination)
- Pack Size: 30 Tablets
- Manufacturer: Merck Serono
- Indication: Type 2 Diabetes Mellitus
- Rx Status: Prescription required
Mechanism of Action
Metformin reduces hepatic glucose output and improves peripheral insulin sensitivity (biguanide). Glibenclamide 5mg (higher strength than the 2.5mg formulation) stimulates insulin secretion from pancreatic beta cells (sulfonylurea), providing stronger combined blood glucose control in patients requiring more intensive therapy.
Important Safety Information
- Use only under the supervision of a qualified physician or diabetologist.
- The 5mg Glibenclamide strength carries a higher risk of hypoglycaemia — monitor blood glucose closely.
- Monitor renal function regularly as directed.
- Do not skip meals after taking this medication.
Usage & Benefits
- Higher-Strength Glibenclamide: Contains Glibenclamide 5mg — twice the sulfonylurea dose of the 2.5mg formulation — for patients requiring stronger insulin secretion stimulation.
- Dual-Mechanism Control: Metformin reduces hepatic glucose output and improves insulin sensitivity, while Glibenclamide 5mg stimulates insulin secretion for complementary blood glucose management.
- Established Combination: Metformin + Glibenclamide is a widely used fixed-dose combination in Type 2 diabetes treatment guidelines.
- Convenient 30-Tablet Pack: Monthly supply for consistent diabetes management.
How To Use
1. Use as directed by your physician or diabetologist. Typically taken with meals to reduce gastrointestinal effects. Monitor blood glucose closely — the 5mg Glibenclamide strength carries higher hypoglycaemia risk. Do not alter the dose or discontinue without medical advice.
FAQs
What is Glucovance 500/5mg used for?
It is prescribed for the management of Type 2 diabetes mellitus, especially for patients requiring stronger blood glucose control.
What are the active ingredients?
Metformin 500mg (biguanide) and Glibenclamide 5mg (sulfonylurea).
Is this available without a prescription?
No, antidiabetic medications require a valid prescription in Pakistan.
How does this differ from Glucovance 500/2.5mg?
This formulation contains Glibenclamide 5mg (higher strength sulfonylurea). The 500/2.5mg formulation contains Glibenclamide 2.5mg (lower strength). Your doctor will prescribe the appropriate dose based on your clinical needs.
Who manufactures Glucovance 500/5mg?
It is manufactured by Merck Serono.
