IVERMEC TABLETS 3mg
IVERMEC TABLETS (Ivermectin)
Potent Anthelmintic Agent: Ivermec (Ivermectin) Tablets U.S.P. 3mg serve as a powerful solution for treating Strongyloidiasis and Onchocerciasis, offering effective relief from these parasitic infections
Unique Mode of Action: Acting through a distinctive mechanism, Ivermectin selectively binds to specific ion channels in invertebrates, leading to their paralysis and subsequent death, while having minimal impact on mammalian cells
Proven Pharmacokinetics: Ivermectin demonstrates a direct relationship between plasma concentrations and dosage, with rapid metabolism in the liver and excretion primarily through feces, ensuring a predictable half-life in the human body
Cautious Usage in Specific Populations: While Ivermectin is generally safe, its use in pregnant women and nursing mothers requires careful consideration due to limited data. Similarly, special attention must be paid to pediatric and geriatric populations to ensure safe and effective treatment
Ivermec Tablets USP 3mg: A Potent Anthelmintic Agent
Composition:
Each tablet of Ivermec USP 3mg contains 3mg of Ivermectin USP.
Description:
Ivermec (Ivermectin) is a semisynthetic anthelmintic agent administered orally. Derived from the avermectins, a class of potent broad-spectrum anti-parasitic agents isolated from Streptomyces avermitilis fermentation products.
Clinical Pharmacology:
Mechanism of Action: Ivermectin, a part of the avermectin class, selectively binds to gluta mate-gated chloride ion channels in invertebrate nerve and muscle cells. This binding increases cell membrane permeability to chloride ions, leading to parasite paralysis and death. It may interact with other ligand-gated chloride channels.
Pharmacodynamics:
Avermectins exhibit specificity due to the absence of glutamate-gated chloride channels in some mammals and their low affinity for mammalian ligand-gated chloride channels. Ivermectin has limited ability to cross the human blood-brain barrier and is effective against various nematodes, excluding adult Onchocerca volvulus.
Pharmacokinetics:
Upon oral intake, plasma Ivermectin concentrations correlate with dosage. Metabolism mainly occurs in the liver, with both Ivermectin and its metabolites primarily excreted in feces over about 12 days. Less than 1% is excreted in urine, with an approximate 18-hour plasma half-life.
Indications and Usage:
Ivermectin is indicated for treating:
- Strongyloidiasis of the intestinal tract
- Onchocerciasis
Contraindications:
Patients hypersensitive to any component of the product should not use Ivermectin.
Interactions:
Co-administration with warfarin may increase International Normalized Ratio (INR) based on post-marketing reports.
Use in Specific Populations:
- Pregnancy: Pregnancy Category C - avoid use.
- Nursing mothers should exercise caution as Ivermectin excretes in low concentrations in human milk.
- Pediatric Use: Safety in pediatric patients <15 kg not established.
- Geriatric Use: Caution in elderly due to potential decreased hepatic, renal, or cardiac function.
- Strongyloidiasis in Immunocompromised Hosts: Administer cautiously to immunocompromised patients.
Conclusion:
In conclusion, Ivermec (Ivermectin) Tablets USP 3mg effectively treats Strongyloidiasis and Onchocerciasis. However, its usage requires careful consideration due to specific populations, potential drug interactions, and contraindications for safe and effective use.
Usage of Ivermec Tablets USP 3mg
Ivermec Tablets USP 3mg are used to treat parasitic infections such as:
- Strongyloidiasis (intestinal roundworm infection)
- Onchocerciasis (river blindness)
Benefits of Ivermec Tablets USP 3mg
- Effective against a broad range of parasitic infections.
- Reduces symptoms like itching and skin rashes associated with parasitic infestations.
- Works quickly to kill parasites and improve overall health.
- Safe when used as prescribed by a healthcare provider.
How to Use Ivermec Tablets USP 3mg
Take Ivermec Tablets USP 3mg exactly as prescribed by your healthcare provider. The typical dosage depends on the condition being treated. For Strongyloidiasis or Onchocerciasis, your doctor will determine the appropriate dose based on your health condition.
Swallow the tablet whole with a glass of water. Do not chew or crush the tablet. It’s essential to take the medication at the prescribed intervals to ensure its effectiveness. Always follow your doctor's instructions carefully.
1. What is Ivermec Tablets USP 3mg used for?
Ivermec Tablets USP 3mg is primarily used to treat parasitic infections such as Strongyloidiasis of the intestinal tract and Onchocerciasis. It works by paralyzing and killing the parasites responsible for these conditions.
2. How does Ivermec Tablets USP 3mg work?
Ivermectin, the active ingredient in Ivermec Tablets, selectively binds to glutamate-gated chloride ion channels in parasites, increasing their cell membrane permeability to chloride ions. This results in parasite paralysis and death, effectively treating the infection.
3. Can Ivermec Tablets be taken with other medications?
There may be drug interactions. For example, co-administration with warfarin may increase the International Normalized Ratio (INR), so consult your healthcare provider before combining it with other medications.
4. Are there any side effects associated with Ivermec Tablets USP 3mg?
Common side effects may include dizziness, headache, nausea, or stomach upset. Serious side effects can occur, so it's important to follow your doctor's recommendations and report any severe symptoms immediately.
5. Who should not use Ivermec Tablets USP 3mg?
Ivermec Tablets should not be used by individuals who are hypersensitive to Ivermectin or any of its components. It is also not recommended during pregnancy, and caution is advised for nursing mothers and pediatric patients under 15 kg.