Paromax CR 37.5mg Tablets – Paroxetine Controlled Release
Paromax CR 37.5mg contains Paroxetine Hydrochloride in a controlled-release formulation — the highest CR dose of this SSRI. It is prescribed for Major Depressive Disorder, OCD, panic disorder, social anxiety, PTSD, GAD, and PMDD. As the most potent CYP2D6 inhibitor among SSRIs, paroxetine requires careful drug interaction review. Never stop without tapering — discontinuation syndrome can be severe due to the short half-life (~21 hours). Prescription required.
Pay in 3 Installments of
Rs.
655
Paromax Cr 37.5mg Tablets – Paroxetine Controlled Release
Description
Paromax CR 37.5mg Tablets — Paroxetine Controlled Release
Paromax CR 37.5mg Tablets contain Paroxetine Hydrochloride in a controlled-release formulation — an SSRI (Selective Serotonin Reuptake Inhibitor) and the strongest CYP2D6 inhibitor among SSRIs. The controlled-release design delivers the active ingredient gradually over 24 hours, reducing peak-related side effects such as nausea and fatigue while maintaining consistent therapeutic plasma levels.
Approved Clinical Indications
- Major Depressive Disorder (MDD) — first-line Rx-grade treatment
- Panic Disorder — with or without agoraphobia
- Obsessive-Compulsive Disorder (OCD)
- Social Anxiety Disorder (Social Phobia)
- Post-Traumatic Stress Disorder (PTSD)
- Generalised Anxiety Disorder (GAD)
- Premenstrual Dysphoric Disorder (PMDD)
Important Clinical Notes
- CYP2D6 inhibition: Paroxetine is the most potent CYP2D6 inhibitor among SSRIs — significant drug interactions possible with codeine, tamoxifen, TCAs, antipsychotics, and other CYP2D6 substrates. Always review full drug list with prescriber.
- Discontinuation syndrome: Due to its short half-life (~21 hours), abrupt stoppage can cause dizziness, electric-shock sensations, irritability, and flu-like symptoms. Always taper under medical supervision — never stop suddenly.
- Anticholinergic effects: Dry mouth, constipation, urinary retention, blurred vision — more pronounced than other SSRIs.
- Weight gain: More common with paroxetine than other SSRIs — discuss with prescriber for long-term management.
- Serotonin syndrome risk: Do not combine with MAOIs, triptans, tramadol, linezolid, or other serotonergic agents without prescriber guidance.
Prescription Required
This is a prescription-only medication. A valid Rx from a licensed physician is required before dispensing. Send your prescription to sales@derma.pk or WhatsApp +92-320-5999650.
Browse related categories: Anti-Depressants | Anti-Anxiety Medicines | Prescription Medicines
Usage & Benefits
- MDD treatment: First-line Rx-grade SSRI for major depressive disorder with proven efficacy
- Controlled-release advantage: Gradual release reduces nausea and improves tolerability vs. immediate-release
- Broad anxiety coverage: Indicated for OCD, panic disorder, social anxiety, GAD, PTSD, and PMDD
- Consistent plasma levels: CR formulation maintains steady serotonin reuptake inhibition over 24 hours
- Established profile: Decades of clinical evidence supporting safety and efficacy under medical supervision
How To Use
Take exactly as prescribed by your doctor — typically once daily in the morning with or without food. Swallow the tablet whole; do not crush or chew (this destroys the controlled-release mechanism). Do not stop or adjust dose without medical guidance. Stopping abruptly can cause severe discontinuation syndrome (dizziness, electric-shock sensations, flu-like symptoms) due to paroxetine's short half-life. Periodic review of all co-medications is essential given paroxetine's strong CYP2D6 inhibitory activity.
FAQs
What is Paromax CR 37.5mg used for?
It is prescribed for Major Depressive Disorder, OCD, panic disorder, social anxiety disorder, PTSD, generalised anxiety disorder, and PMDD — all conditions involving serotonin dysregulation.
Why is paroxetine considered a strong CYP2D6 inhibitor?
Paroxetine irreversibly inhibits CYP2D6, the enzyme that metabolises many drugs including codeine, tamoxifen, and tricyclic antidepressants. This means adding or stopping paroxetine can significantly alter levels of co-prescribed medications.
Why should I not stop Paromax CR suddenly?
Paroxetine has a short half-life (~21 hours) with no active metabolites, making it the SSRI most prone to discontinuation syndrome. Abrupt stopping can cause dizziness, sensory disturbances, irritability, and insomnia. Always taper under prescriber guidance.
How long before Paromax CR starts working?
Symptom improvement typically begins at 2–4 weeks; full therapeutic benefit may take 6–8 weeks. Continue the medication as prescribed even if you do not feel immediate improvement.
Dermatologist Recommended
Healer's Pharma Minoxidil 5% + Finasteride 0.25% Hair Regrowth Spray
0.25% Finasteride Topical Hair Loss Spray by Healer's Pharma
