Pequit 25mg Tablets – Quetiapine Fumarate for Schizophrenia Treatment
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Description
Pequit 25mg Tablets — Quetiapine Fumarate (Immediate Release)
Pequit 25mg Tablets contain Quetiapine Fumarate, a second-generation (atypical) antipsychotic. At lower doses such as 25mg, quetiapine's antihistamine (H1) receptor blockade dominates — producing marked sedation and anxiolysis. It is the entry dose for titration in schizophrenia and bipolar disorder, and is prescribed by specialists for various indications depending on clinical context.
Approved Clinical Indications
- Schizophrenia — initiation and titration toward therapeutic doses
- Bipolar I Disorder — manic and mixed episodes (titration starting dose)
- Bipolar Depression
- Adjunct MDD therapy — under psychiatrist supervision
Important Clinical Notes & Monitoring
- Dose titration: 25mg is typically the starting dose; titrate per clinical response and tolerability — do not self-adjust.
- Metabolic monitoring: Monitor weight, fasting glucose, and lipids at baseline and periodically — metabolic syndrome risk.
- Orthostatic hypotension: Most pronounced at low doses due to alpha-1 blockade — titrate slowly and advise patients to rise slowly.
- Sedation: Strong at this dose due to H1 activity — caution with driving, machinery, and CNS depressants.
- QTc prolongation: ECG monitoring advised, especially with concomitant QT-prolonging drugs.
- Cataract risk: Eye examination recommended for long-term therapy.
Prescription Required
This is a prescription-only medication. Send your valid Rx to sales@derma.pk or WhatsApp +92-320-5999650.
Browse related: Anti-Psychotics | Prescription Medicines | General Medicines
Usage & Benefits
- Safe initiation: 25mg is the recommended starting dose to minimise orthostatic hypotension and excessive sedation during titration
- Schizophrenia: Effective for both positive and negative symptom management when titrated to therapeutic doses
- Bipolar disorder: Mood stabilisation for manic, mixed, and depressive episodes
- Reduced EPS: Lower extrapyramidal side effect risk compared to first-generation antipsychotics
- Sedation benefit: Antihistamine-mediated sedation can aid sleep in agitated patients during the acute phase
How To Use
Take exactly as prescribed by your psychiatrist. Titrate slowly as directed — never jump to a higher dose without medical guidance. Take with food if stomach upset occurs. Rise slowly from sitting or lying down to avoid orthostatic hypotension. Avoid alcohol and sedatives. Do not stop suddenly. Monitor weight, fasting glucose, and blood pressure at baseline and periodically. Report any vision changes or unusual muscle movements.
FAQs
Why is 25mg the starting dose of Quetiapine?
At low doses, quetiapine's alpha-1 adrenergic blockade can cause significant blood pressure drops (orthostatic hypotension). Starting at 25mg allows the body to adapt before dose escalation.
How long does it take to reach the effective dose?
Typically 4–7 days of gradual titration to reach a therapeutic dose range (150–300mg for schizophrenia, 300–400mg for bipolar mania). Your prescriber will guide the schedule.
Is Pequit 25mg only used for schizophrenia?
While primarily indicated for schizophrenia and bipolar disorder, the 25mg dose is also used as a starting point for adjunct MDD therapy under specialist supervision.
Can Pequit 25mg cause weight gain?
Yes. Weight gain is a class effect of quetiapine. Monitoring diet, exercise, and metabolic parameters is important throughout treatment.
