Pequit XR 300mg Tablets – Quetiapine Fumarate Extended Release
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Description
Pequit XR 300mg Tablets — Quetiapine Fumarate Extended Release
Pequit XR 300mg Tablets contain Quetiapine Fumarate in an extended-release formulation at the standard maintenance dose for schizophrenia and bipolar disorder. The XR technology ensures once-daily dosing with a flatter plasma profile compared to IR tablets — reducing peak-driven sedation while maintaining 24-hour antipsychotic and mood-stabilising coverage.
Approved Clinical Indications
- Schizophrenia — maintenance therapy and acute episode management
- Bipolar I Disorder — acute mania and depressive episodes
- Bipolar II Depression
- Adjunct MDD — when combined with an antidepressant under specialist supervision
XR Formulation Advantages
- Once-daily dosing at 300mg — typical maintenance dose for schizophrenia
- Reduced peak sedation vs. IR formulation
- Sustained 5-HT2A and D2 receptor blockade throughout the day
- Swallow whole — do not crush, split, or chew (destroys XR mechanism)
Important Clinical Notes & Monitoring
- Metabolic monitoring: Weight, fasting glucose, HbA1c, and lipid panel at baseline and every 3–6 months — metabolic syndrome is a class risk.
- QTc prolongation: Avoid combining with other QT-prolonging agents; ECG monitoring in at-risk patients.
- Cataract risk: Lens monitoring recommended for long-term use.
- Avoid alcohol: Additive CNS depression; also avoid grapefruit juice (CYP3A4 interaction).
- Carbapenem antibiotic interaction: Not applicable for quetiapine, but review all co-medications with prescriber.
Prescription Required
This is a prescription-only medication. Send your valid Rx to sales@derma.pk or WhatsApp +92-320-5999650.
Browse related: Anti-Psychotics | Prescription Medicines | General Medicines
Usage & Benefits
- Standard maintenance dose: 300mg is the typical target dose range for schizophrenia in adults
- Once-daily XR convenience: Simplified dosing schedule supports treatment adherence
- Bipolar efficacy: Proven efficacy for both manic and depressive phases of bipolar disorder
- Smooth plasma coverage: Extended-release provides sustained 5-HT2A and D2 blockade with reduced sedation peaks
- Adjunct MDD option: Can be added to antidepressant therapy under specialist supervision for treatment-resistant depression
How To Use
Take exactly as prescribed by your psychiatrist — once daily, typically at bedtime. Swallow whole; do not crush or split. Avoid alcohol and grapefruit juice (CYP3A4 interaction). Do not stop suddenly — consult your prescriber before any dose change. Monitor weight, fasting glucose, HbA1c, and lipid panel at baseline and every 3–6 months. ECG monitoring advised in patients with cardiac risk factors. Eye examination recommended for long-term use.
FAQs
Why is 300mg considered a standard maintenance dose?
Clinical guidelines recommend 300–600mg/day as the maintenance range for schizophrenia with quetiapine XR. 300mg provides sufficient receptor occupancy for symptom control in many patients.
Can I take Pequit XR 300mg with grapefruit juice?
No. Grapefruit juice inhibits CYP3A4, the enzyme that metabolises quetiapine, potentially increasing drug levels and side effects. Use water instead.
How long will I need to take Quetiapine XR?
Schizophrenia is a chronic condition typically requiring long-term or lifelong maintenance therapy. Your psychiatrist will review treatment duration based on clinical response and tolerance.
What happens if I stop Pequit XR suddenly?
Abrupt discontinuation can cause rebound symptoms including insomnia, nausea, and agitation, and risks relapse of the underlying condition. Always taper under medical supervision.
