Piozer 45mg Tablet
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Description
Piozer 45mg Tablet (Pioglitazone)
Piozer 45mg Tablet contains Pioglitazone 45mg, the maximum approved oral dose of this thiazolidinedione (TZD) antidiabetic agent. It is used in the management of type 2 diabetes mellitus when lower doses (15mg or 30mg) have not achieved adequate glycaemic control. Pioglitazone acts as an agonist of PPAR-gamma receptors in adipose tissue and muscle, improving insulin sensitivity and reducing fasting blood glucose levels.
Piozer 45mg is commonly prescribed in combination with Metformin, Sitagliptin, or Sulfonylureas for optimised diabetes management. It helps lower the long-term risk of diabetic complications including kidney failure, peripheral neuropathy, retinopathy, and major cardiovascular events.
Important Safety Information
- Bladder cancer risk: Prolonged use (>1 year) is associated with an increased risk of bladder cancer. Report haematuria, dysuria, or urinary frequency immediately.
- Heart failure: Pioglitazone causes dose-dependent fluid retention, which can precipitate or worsen heart failure. Contraindicated in NYHA Class III/IV heart failure.
- Fluid retention/oedema: Monitor for peripheral and pulmonary oedema, particularly in patients with cardiac or renal disease.
- Bone fracture risk: Long-term use is associated with increased fracture risk, particularly in female patients. Evaluate bone health before initiation.
- Weight gain: Dose-dependent weight gain is expected; monitor BMI and advise dietary adjustments.
- Hepatotoxicity: Rare but reported; check liver function if jaundice or elevated enzymes are suspected.
- Macular oedema: Monitor for visual changes; refer for ophthalmological evaluation if symptoms develop.
Prescription required. Do not self-medicate. Available from Derma.pk Tablets & Capsules with nationwide delivery across Pakistan. Call/WhatsApp: +92-320-5999650.
Usage & Benefits
- Maximum-dose Pioglitazone for patients requiring intensified insulin sensitisation
- Significantly improves HbA1c and fasting blood glucose in type 2 diabetes
- Effective in combination with Metformin, Sitagliptin, or Sulfonylureas
- Reduces risk of long-term diabetic complications including nephropathy and retinopathy
- Supports comprehensive glycaemic management as part of a diabetes care plan
How To Use
Dosage and duration as prescribed by your physician. Typically taken once daily with or without food. Do not alter the dose or discontinue without medical advice. Regularly monitor blood glucose, liver function, and body weight. Report oedema, visual changes, haematuria, or signs of cardiac decompensation immediately. Prescription required — not for self-medication.
FAQs
What is Piozer 45mg used for?
It is the highest available dose of Pioglitazone, used for type 2 diabetes when lower doses are insufficient. It improves insulin sensitivity via PPAR-gamma activation.
What is the bladder cancer warning for Piozer 45mg?
Prolonged use (greater than 1 year) is associated with an increased risk of bladder cancer. Report any blood in the urine, pain on urination, or increased urinary frequency immediately to your physician.
Why is Pioglitazone contraindicated in heart failure?
Pioglitazone causes dose-dependent fluid retention which can precipitate or worsen cardiac failure. It is strictly contraindicated in NYHA Class III/IV heart failure.
Are women at higher fracture risk with Piozer?
Yes. Long-term Pioglitazone therapy is associated with increased fracture risk particularly in women. Bone health should be evaluated before and during therapy.
