Qosmet 50/500mg Tablets are a fixed-dose combination containing Sitagliptin 50mg, a DPP-4 (dipeptidyl peptidase-4) inhibitor, and Metformin 500mg, a biguanide antidiabetic agent. This combination targets two complementary mechanisms in Type 2 diabetes management: Sitagliptin enhances incretin-mediated insulin secretion and suppresses glucagon in a glucose-dependent manner, while Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity. Together they provide additive glycaemic control with a lower risk of hypoglycaemia compared to sulphonylurea-based regimens.

Qosmet 50/500mg is indicated for adults with Type 2 diabetes whose blood glucose is inadequately controlled on metformin alone, or as an initial combination therapy for patients requiring both DPP-4 inhibition and metformin. It should be taken with meals to reduce gastrointestinal side effects from metformin. Regular HbA1c monitoring is recommended to assess glycaemic response. Renal function should be checked before initiation and periodically thereafter, as dose adjustment is required for moderate-to-severe renal impairment.

Common side effects include nausea, diarrhoea, headache, and upper respiratory infections. Rare but serious adverse effects include pancreatitis and lactic acidosis (a rare complication of metformin) — seek immediate medical care for severe abdominal pain, persistent vomiting, or muscle weakness. A valid prescription is required for this medicine.

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