VORIF Tablets 200mg - Antifungal Medication for Effective Treatment
VORIF TABLETS (Voriconazole tablets)
VORIF, containing Voriconazole, demonstrates potent antifungal activity by inhibiting fungal cytochrome P-450 enzymes crucial for ergosterol biosynthesis.
Indicated for invasive aspergillosis, esophageal candidiasis, candidemia, and serious fungal infections, VORIF addresses a spectrum of fungal challenges in both adults and children.
The dosage regimen, including a loading dose for the first 24 hours, ensures rapid achievement of therapeutic plasma concentrations. Subsequent maintenance doses vary based on patient weight.
While generally well-tolerated, users should be mindful of potential adverse reactions, including hypokalemia, visual changes, and, rarely, serious events like pancreatitis or Stevens-Johnson syndrome.
VORIF is contraindicated in cases of hypersensitivity to voriconazole components and when co administered with specific drugs like rifampin, ritonavir, and carbamazepine due to potential interactions
VORIF TABLETS
Composition:
Each filmcoated tablet contains Voriconazole 50mg and 200mg respectively
Ferozsons Specifications:
Drug Description VORIF TABLETS:
Voriconazole is a triazole antifungal agent with the chemical designation (2R,3S)2(2,4difluorophenyl)3(5fluoro4pyrimidinyl)1(1H1,2,4triazol1yl)2butanol It inhibits fungal cytochrome P450mediated 14 alphalanosterol demethylation, a crucial step in fungal ergosterol biosynthesis
Clinical Pharmacology:
Mode of Action: Inhibition of fungal cytochrome P450 enzymes VORIF TABLETS
Pharmacodynamics/Kinetics: Well absorbed orally, selective for fungal cytochrome P450, hepatic metabolism, bioavailability of 96%, variable elimination half life
Indications: Invasive aspergillosis, esophageal candidiasis, candidemia, disseminated Candida infections, serious fungal infections caused by specific species
Dosage and Administration:
Loading Dose (First 24 hours):
Patients 40kg and above: 400mg every 12 hours
Patients less than 40kg: 200mg every 12 hours
Maintenance Dose (After the first 24 hours):
Patients 40kg and above: 200mg twice a day
Patients less than 40kg: 100mg twice a day
Recommended Duration: Minimum of 14 days, with at least 7 days post symptom resolution
Dosing in Special Populations:
Renal Insufficiency: No dose adjustment necessary
Hepatic Impairment: Reduce maintenance dosage by 50% in mild to moderate cases; caution in severe impairment
Elderly: Follow adult dosing
Teenagers 12 to 14 years (50kg or more): 400mg every 12 hours for the first 24 hours, then 200mg twice a day
Adverse Reactions:
Common (210%): Hypokalemia, visual changes, fever, nausea
<2% (Important or life threatening): Acute tubular necrosis, pancreatitis, respiratory distress syndrome, Stevens Johnson syndrome, and more
Contraindications VORIF TABLETS:
Hypersensitivity to voriconazole or its components
Co-administration with certain drugs, including rifampin, ritonavir, carbamazepine, and others
Warnings/Precautions:
Arrhythmias/QT Prolongation: Caution in patients with risk factors; correct electrolyte abnormalities
Dermatologic Reactions: Monitor for photosensitivity; discontinue for severe reactions
Hallucinations: Mostly with IV formulation; caution is advised
Pregnancy and Lactation:
Pregnancy Risk Factor: D (Benefit to mother justifies potential risk to the fetus)
Excretion in breast milk is unknown; not recommended during lactation
Drug Interactions:
Contraindicated with drugs like rifampin, ritonavir, carbamazepine, etc
Significant interactions with fluconazole, cimetidine, ranitidine, and others; dosage adjustment may be necessary
Storage:
Store at 1530 °C in a dry and dark place Keep out of the reach of children
How Supplied:
Vorif 50mg & 200mg Tablets are available in 1x10's Blister Pack
Please read the contents cautiously before use This package insert is regularly and timely updated
Usage and Benefits of VORIF Tablets
- Effective Against Serious Fungal Infections: VORIF Tablets are used to treat invasive aspergillosis, candidiasis, and other serious fungal infections.
- Anti-Fungal Action: Voriconazole targets the growth of fungi by inhibiting key enzymes, preventing fungal cell growth and reproduction.
- Well-Tolerated: VORIF is well absorbed, with a bioavailability of 96%, ensuring effective treatment for a variety of fungal infections.
- Flexible Dosing: VORIF offers both a loading dose and maintenance dose regimen, tailored to the patient’s needs, including for children and elderly populations.
- Specialized Treatment for Complex Infections: Ideal for treating difficult fungal infections that require specialized therapy, including esophageal candidiasis and candidemia.
How to Use VORIF Tablets
VORIF Tablets should be used as directed by your healthcare provider. For most infections:
- Loading Dose: Administer 400mg every 12 hours for patients 40kg and above, or 200mg for those under 40kg for the first 24 hours.
- Maintenance Dose: After 24 hours, take 200mg twice daily (for patients over 40kg) or 100mg twice daily (for patients under 40kg).
- For Specific Populations: In cases of renal insufficiency, no dose adjustment is needed. For hepatic impairment, reduce the maintenance dosage by 50% in mild to moderate cases.
Follow your physician’s recommendations for dosage duration. Typically, VORIF is prescribed for a minimum of 14 days, with at least 7 days post-symptom resolution.
Frequently Asked Questions (FAQs) about VORIF Tablets
1. What is VORIF Tablets used for?
VORIF Tablets, containing Voriconazole, are used to treat serious fungal infections like invasive aspergillosis, esophageal candidiasis, candidemia, and disseminated Candida infections. It is also used for treating fungal infections caused by specific species.
2. How does VORIF work?
Voriconazole in VORIF Tablets works by inhibiting fungal cytochrome P450 enzymes, specifically the 14α-lanosterol demethylation process, which is essential for fungal ergosterol biosynthesis. This action helps to prevent the growth and spread of fungal infections.
3. What is the dosage for VORIF Tablets?
The loading dose for VORIF Tablets is 400mg every 12 hours for patients over 40kg and 200mg for those under 40kg during the first 24 hours. The maintenance dose for adults is 200mg twice a day (or 100mg for patients less than 40kg). Dosage adjustments are needed for specific populations like those with hepatic impairment or the elderly.
4. What are the common side effects of VORIF Tablets?
Common side effects include hypokalemia, visual changes, fever, and nausea. In rare cases, VORIF may cause more serious side effects like acute tubular necrosis, pancreatitis, or Stevens-Johnson syndrome. If you experience severe reactions, contact your healthcare provider immediately.
5. Are there any drug interactions with VORIF Tablets?
VORIF Tablets are contraindicated when used with certain drugs, including rifampin, ritonavir, and carbamazepine. Significant interactions may also occur with fluconazole, cimetidine, and ranitidine, so dosage adjustments may be required. Always consult with your healthcare provider before starting new medications.