VORIF TABLETS 50mg
VORIF TABLETS (Voriconazole tablets)
VORIF, containing Voriconazole, demonstrates potent antifungal activity by inhibiting fungal cytochrome P-450 enzymes crucial for ergosterol biosynthesis.
Indicated for invasive aspergillosis, esophageal candidiasis, candidemia, and serious fungal infections, VORIF addresses a spectrum of fungal challenges in both adults and children.
The dosage regimen, including a loading dose for the first 24 hours, ensures rapid achievement of therapeutic plasma concentrations. Subsequent maintenance doses vary based on patient weight.
While generally well-tolerated, users should be mindful of potential adverse reactions, including hypokalemia, visual changes, and, rarely, serious events like pancreatitis or Stevens-Johnson syndrome.
VORIF is contraindicated in cases of hypersensitivity to voriconazole components and when co administered with specific drugs like rifampin, ritonavir, and carbamazepine due to potential interactions
VORIF: Voriconazole Tablets (50mg & 200mg)
Composition:
VORIF TABLETS Each filmcoated
tablet contains Voriconazole 50mg and 200mg respectively
Ferozsons Specifications:
Drug Description:
Voriconazole is a triazole antifungal agent with the chemical designation (2R,3S)2(2,4difluorophenyl)3(5fluoro4pyrimidinyl)1(1H1,2,4triazol1yl)2butanol
It inhibits fungal cytochrome P450mediated 14 alphalanosterol demethylation, a
crucial step in fungal ergosterol biosynthesis
Clinical Pharmacology:
Mode of Action:
Inhibition of fungal cytochrome P450 enzymes
Pharmacodynamics/Kinetics: Well absorbed
orally, selective for fungal cytochrome P450, hepatic metabolism, bioavailability
of 96%, variable elimination half life
Indications: Invasive
aspergillosis, esophageal candidiasis, candidemia, disseminated Candida
infections, serious fungal infections caused by specific species
Dosage and Administration:
Loading Dose (First
24 hours):
Patients 40kg and above: 400mg every 12 hours
Patients less than 40kg: 200mg every 12 hours
Maintenance Dose
(After the first 24 hours):
Patients 40kg and above: 200mg twice a day
Patients less than 40kg: 100mg twice a day
Recommended Duration:
Minimum of 14 days, with at least 7 days post symptom resolution
Dosing in Special Populations:
Renal Insufficiency:
No dose adjustment necessary
Hepatic Impairment:
Reduce maintenance dosage by 50% in mild to moderate cases; caution in severe
impairment
Elderly: Follow adult
dosing
Teenagers 12 to 14
years (50kg or more): 400mg every 12 hours for the first 24 hours, then 200mg
twice a day
Adverse Reactions:
Common (210%):
Hypokalemia, visual changes, fever, nausea
<2% (Important or
life threatening): Acute tubular necrosis, pancreatitis, respiratory distress
syndrome, Stevens Johnson syndrome, and more
Contraindications:
- Hypersensitivity to
voriconazole or its components - Co-administration with
certain drugs, including rifampin, ritonavir, carbamazepine, and others
Warnings/Precautions:
- Arrhythmias/QT
Prolongation: Caution in patients with risk factors; correct electrolyte
abnormalities - Dermatologic
Reactions: Monitor for photosensitivity; discontinue for severe reactions - Hallucinations:
Mostly with IV formulation; caution is advised
Pregnancy and Lactation:
Pregnancy Risk
Factor: D (Benefit to mother justifies potential risk to the fetus)
Excretion in breast
milk is unknown; not recommended during lactation
Drug Interactions:
Contraindicated with
drugs like rifampin, ritonavir, carbamazepine, etc
Significant
interactions with fluconazole, cimetidine, ranitidine, and others; dosage
adjustment may be necessary
Storage:
Store at 1530 °C in a
dry and dark place Keep out of the reach of children
How Supplied:
Vorif 50mg &
200mg Tablets are available in 1x10's Blister Pack
Please read the contents cautiously before use This package
insert is regularly and timely updated
Usage and Benefits of Vorif Tablet
- Effective Treatment for Serious Infections: Vorif is highly effective against a wide range of serious fungal infections, including invasive aspergillosis and candidiasis, providing comprehensive systemic treatment.
- Broad-Spectrum Action: It works against multiple fungal species, including those resistant to other antifungal medications, like fluconazole-resistant Candida infections.
- Selective Inhibition: Vorif selectively inhibits fungal cytochrome P450 enzymes, making it a targeted treatment option that minimizes damage to healthy cells.
- Convenient Dosing: Vorif is available in convenient tablet form, making it easy to incorporate into daily routines. It is taken twice daily after the initial loading dose.
- Well-Tolerated: Most side effects are mild and transient, including visual disturbances and gastrointestinal symptoms, which are typically manageable and resolve during treatment.
How to Use Vorif Tablet
Follow these instructions to use Vorif tablets effectively:
- Start with the loading dose: For adults and children over 40kg, take 400mg every 12 hours for the first 24 hours.
- After the first 24 hours, reduce the dose to 200mg twice a day for patients over 40kg and 100mg twice daily for those under 40kg.
- Take Vorif with a glass of water, preferably on an empty stomach or with food as directed by your healthcare provider.
- Do not exceed the prescribed dose, and follow up with your doctor for any adjustments or concerns regarding treatment duration.
It is important to monitor your condition regularly and inform your doctor of any side effects you experience during treatment.
1. What is Vorif used for?
VORIF (Voriconazole) is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis, esophageal candidiasis, and disseminated Candida infections. It is also effective for treating fungal infections caused by specific species like Fusarium and Scedosporium spp.
2. How does Vorif work?
Vorif works by inhibiting fungal cytochrome P450 enzymes, specifically the 14α-lanosterol demethylation process, which is crucial for the biosynthesis of ergosterol, a vital component of fungal cell membranes. This action leads to the disruption of the fungal cell membrane and ultimately causes cell death.
3. What is the recommended dosage of Vorif?
The loading dose for adults and children over 40kg is 400mg every 12 hours for the first 24 hours. After 24 hours, the maintenance dose is reduced to 200mg twice a day for patients over 40kg. For those under 40kg, the loading dose is 200mg every 12 hours, followed by 100mg twice daily as a maintenance dose. Always follow your doctor’s guidance for specific dosing adjustments.
4. What are the common side effects of Vorif?
Common side effects of Vorif include visual disturbances, fever, hypokalemia (low potassium levels), and nausea. These side effects are typically mild to moderate, but if they persist or worsen, consult your healthcare provider.
5. Can Vorif be used during pregnancy or breastfeeding?
Vorif is classified as a pregnancy risk category D, meaning it should only be used if the benefits to the mother outweigh the risks to the fetus. It is also excreted in breast milk, so breastfeeding is not recommended during treatment.