Cleret Gel 20g
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Description
Cleret Gel: Comprehensive Overview and Usage Guide
Description:
Cleret Gel is a unique blend of Clindamycin Phosphate, a water-soluble antibiotic, and Tretinoin, a retinoid. Clindamycin inhibits bacterial protein synthesis, while Tretinoin decreases microcomedo formation and promotes follicular cell turnover.
Composition:
Each gram contains:
- Clindamycin Phosphate 1.20% w/w
- Tretinoin 0.0259% w/w
Indications:
Primarily for topical treatment of acne vulgaris in patients aged 12 years and older.
Pharmacokinetics:
Cleret Gel shows minimal percutaneous absorption of Tretinoin. Plasma concentrations for Tretinoin generally range from 1.0 to 1.6 ng/mL, while Clindamycin concentrations usually stay below 3.5 ng/mL.
Dosage and Administration:
Apply a peasized amount at bedtime to the affected areas, gently spreading over the entire face. Avoid contact with eyes, mouth, nose angles, and mucous membranes.
Contraindications:
Avoid use in patients with regional enteritis, ulcerative colitis, or a history of antibiotic-associated colitis.
Warnings and Precautions:
Discontinue Cleret Gel if significant diarrhea occurs. Use sunscreen during treatment due to increased skin sensitivity to sunlight.
Adverse Reactions:
Common reactions include nasopharyngitis, dry skin, and local skin reactions like erythema, scaling, itching, burning, and stinging.
Drug Interactions:
Use medicated soaps or cosmetics with strong drying effects cautiously. Avoid concomitant use with erythromycin-containing products.
Use in Specific Populations:
Use during pregnancy only if the potential benefit justifies the risk. Limited data exists for pediatric and geriatric use.
Nonclinical Toxicology:
No observed teratogenicity in animal studies. Cleret Gel shows no carcinogenic effects, but Tretinoin may enhance photo cocarcinogenicity with UV radiation.
Presentation:
Supplied in 20-gram tubes, available by prescription only.
Instructions:
Store below 25 °C, protect from light and freezing, and keep away from children. For external use only.
Cleret Gel offers an effective topical solution for acne vulgaris. Adhering to administration guidelines and heeding warnings ensures safe and effective usage. Always consult healthcare professionals for personalized advice.
Usage & Benefits
- Clindamycin Phosphate 1.2%: inhibits Cutibacterium acnes (acne-causing bacteria) protein synthesis
- Tretinoin 0.0259%: a retinoid that reduces microcomedo formation and promotes skin cell turnover
- Dual-action formula addresses both the bacterial and comedonal components of acne
- Suitable for moderate-to-severe acne vulgaris in patients aged 12 years and above
- Reduces active breakouts, blackheads, whiteheads, and inflammatory papules
- Promotes exfoliation of dead skin cells to unclog pores and improve skin texture
- Once-nightly application for convenience and tolerability
- Minimal percutaneous absorption of tretinoin — plasma concentrations remain very low
How To Use
- Apply as directed by your dermatologist. Do not self-medicate. Use for the prescribed duration only. General guidance (subject to physician instruction):
- Wash face gently and allow to dry completely before applying
- Apply a pea-sized amount at bedtime to the affected areas, spreading gently over the face
- Avoid contact with eyes, mouth, angles of the nose, and mucous membranes
- Use sunscreen daily during treatment — Tretinoin increases photosensitivity
- Avoid medicated or abrasive soaps and cosmetics with strong drying effects — these may worsen irritation
- Do not use concomitantly with erythromycin-containing topical products
- Discontinue and consult your doctor if significant diarrhoea or GI symptoms develop (rare antibiotic-associated colitis risk)
- PREGNANCY WARNING: Tretinoin is Pregnancy Category C. Do not use during pregnancy. Inform your dermatologist immediately if you become pregnant during treatment
- Store below 25°C, protect from light and freezing. Keep out of reach of children.
FAQs
Is Cleret Gel available without a prescription?
No. Cleret Gel is a strict prescription-only (Rx) medicine containing Clindamycin Phosphate (an antibiotic) and Tretinoin (a retinoid). A valid prescription from a registered dermatologist or medical practitioner is required to purchase this product.
Can I use Cleret Gel during pregnancy?
No. Tretinoin is classified as Pregnancy Category C and should NOT be used during pregnancy. If you are pregnant, planning to become pregnant, or breastfeeding, inform your dermatologist immediately before starting or continuing treatment.
How does Cleret Gel work for acne?
Clindamycin Phosphate inhibits the growth of Cutibacterium acnes (acne bacteria) by blocking bacterial protein synthesis. Tretinoin reduces microcomedo formation and promotes cellular turnover, helping to unclog pores and prevent new acne lesions.
When should I apply Cleret Gel?
Apply a pea-sized amount at bedtime as directed by your dermatologist. Nighttime application is recommended as Tretinoin increases photosensitivity.
Can I use Cleret Gel with other acne products?
Avoid using Cleret Gel with erythromycin-containing topical products or harsh medicated cleansers. Consult your dermatologist before combining with any other acne treatments.
Where can I find more acne treatment options?
Explore our [Tretinoin collection](/collections/tretinoin), [Clindamycin Phosphate products](/collections/clindamycin-phosphate), or [Acne & Pimple Treatments](/collections/pimpacne-le-treatments) for more dermatologist-recommended options.
