Coversam 4mg/5mg Tablets – Perindopril & Amlodipine
Coversam 4mg/5mg Tablets are a fixed-dose combination of Perindopril 4mg (ACE inhibitor) and Amlodipine 5mg (dihydropyridine calcium channel blocker). The 5mg amlodipine dose suits patients requiring a lower CCB starting dose or those with lower blood pressure targets. Perindopril attenuates CCB-induced peripheral oedema. Indicated for hypertension in adults. Prescription only (Rx).
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Coversam 4mg/5mg Tablets – Perindopril & Amlodipine
Description
What is Coversam 4mg/5mg?
Coversam 4mg/5mg Tablets are a fixed-dose combination of Perindopril 4mg (ACE inhibitor) and Amlodipine 5mg (dihydropyridine calcium channel blocker). This combination provides dual-mechanism blood pressure reduction and is indicated for hypertension in adults. The 5mg amlodipine dose is appropriate for patients requiring a lower starting amlodipine dose or those sensitive to the higher 10mg strength.
How Does Coversam 4mg/5mg Work?
Perindopril inhibits ACE, blocking angiotensin II production and reducing aldosterone secretion, which lowers vasoconstriction and blood pressure. Amlodipine 5mg blocks L-type calcium channels in vascular smooth muscle, producing peripheral vasodilation and reducing cardiac afterload. The combination achieves additive antihypertensive effect with reduced peripheral oedema compared to amlodipine monotherapy, as perindopril attenuates CCB-induced fluid retention.
Uses of Coversam 4mg/5mg
Indicated for hypertension in adults where combination therapy with an ACE inhibitor and calcium channel blocker is appropriate. The 4mg/5mg formulation is suited to patients requiring a lower amlodipine dose. For patients needing the higher amlodipine dose, Coversam 4mg/10mg is available.
Dosage & Administration
One tablet (4mg/5mg) once daily, preferably in the morning before or with a meal. Swallow whole. Do not crush or split. Monitor blood pressure response; dose may be titrated by switching to the 4mg/10mg strength if adequate control is not achieved. Reduce dose in renal impairment. Do not stop without medical advice.
Side Effects
ACE inhibitor component: dry persistent cough (class effect), hyperkalaemia, dizziness, first-dose hypotension. Amlodipine 5mg component: peripheral oedema (ankle swelling), flushing, headache, palpitations — generally less pronounced at 5mg than 10mg. Rare but serious: angioedema (discontinue immediately if swelling of face, lips, or tongue occurs).
Precautions
Contraindicated in ACE inhibitor-induced angioedema history, concurrent use of sacubitril/valsartan, pregnancy (teratogenic), and bilateral renal artery stenosis. Monitor renal function, serum electrolytes, and blood pressure regularly. Avoid concomitant potassium supplements or potassium-sparing diuretics unless supervised. Prescription only (Rx). Consult your physician or cardiologist. See also Coversam 4mg/10mg if higher amlodipine dose is required.
Frequently Asked Questions
Q: What is the difference between Coversam 4mg/5mg and 4mg/10mg?
A: The amlodipine dose differs: 5mg vs 10mg. The 4mg/5mg is for patients starting at a lower amlodipine dose or those with lower blood pressure targets. Your doctor determines the appropriate strength.
Q: Can Coversam 4mg/5mg cause ankle swelling?
A: Peripheral oedema (ankle swelling) is an amlodipine class effect. It is generally less common at 5mg than 10mg. Report persistent or worsening oedema to your doctor.
Q: Is Coversam 4mg/5mg available without a prescription in Pakistan?
A: No. Coversam is a prescription-only antihypertensive (Rx). A valid doctor's prescription is required.
Usage & Benefits
- Fixed-dose ACE inhibitor + calcium channel blocker combination
- Lower 5mg amlodipine dose reduces peripheral oedema risk
- Once-daily dosing for sustained 24-hour blood pressure control
- Perindopril attenuates CCB-associated fluid retention
- Suitable for patients needing combination therapy at lower amlodipine doses
- Prescription antihypertensive available in Pakistan at Derma.pk
How To Use
Take one Coversam 4mg/5mg tablet once daily, preferably in the morning before or with a meal. Swallow whole; do not crush or split. Take at the same time each day. If blood pressure remains uncontrolled, your doctor may switch you to Coversam 4mg/10mg. Do not stop without medical advice — abrupt discontinuation may cause rebound hypertension. Prescription required.
FAQs
What is the difference between Coversam 4mg/5mg and 4mg/10mg?
The amlodipine component differs: 5mg versus 10mg. The 4mg/5mg is appropriate for patients who require a lower amlodipine starting dose or have a lower blood pressure target. Your doctor determines the appropriate strength.
Does Coversam 4mg/5mg cause a dry cough?
Dry persistent cough is a class effect of the Perindopril (ACE inhibitor) component. If persistent, consult your doctor — an ARB-based combination may be considered as an alternative.
Is Coversam 4mg/5mg available without a prescription in Pakistan?
No. Coversam is a prescription-only antihypertensive (Rx). A valid doctor's prescription is required for dispensing.
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