Depurch 25mg Tablets – Agomelatine for Depression, Sleep & Mood Regulation
Depurch 25mg tablets contain Agomelatine — a non-SSRI antidepressant acting on melatonin MT1/MT2 and serotonin 5-HT2C receptors. Improves sleep and mood. Liver monitoring required. Rx only at Derma.pk, COD Pakistan.
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Depurch 25mg Tablets – Agomelatine for Depression, Sleep & Mood Regulation
Description
About Depurch 25mg Tablets
Depurch 25mg Tablets contain Agomelatine, a uniquely mechanistic antidepressant with a dual action: it is a melatonin receptor agonist (MT1/MT2) and a serotonin 5-HT2C receptor antagonist. Unlike SSRIs or SNRIs, Agomelatine does not inhibit monoamine reuptake — its antidepressant effect is achieved by resynchronising disrupted circadian rhythms and improving sleep architecture. This makes Depurch valuable for patients where depression is closely linked to sleep disturbance or circadian dysregulation. Critical safety note: Hepatotoxicity risk — liver function tests (LFTs) are required before starting treatment and periodically during use. Contraindicated in hepatic impairment. Use under psychiatrist supervision. Consult your doctor / prescription required.
Key Benefits
- Novel non-SSRI antidepressant — acts on melatonin and serotonin receptors
- Improves sleep quality and restores circadian rhythm alongside antidepressant effect
- No sexual dysfunction or weight gain — key differentiator vs SSRIs
- No significant daytime sedation — taken at bedtime
- Effective for major depressive disorder with comorbid insomnia
How to Use
Take one Depurch 25mg tablet once daily at bedtime as prescribed by your psychiatrist. Swallow whole — do not crush or chew. Take at the same time each night. Do not stop without medical guidance. Your doctor will arrange liver function tests before and during treatment.
FAQs
Q: Is Depurch 25mg a prescription medicine in Pakistan?
A: Yes. It is a prescription-only (Rx) psychiatric medicine. Submit your valid prescription at sales@derma.pk or WhatsApp +92-320-5999650 before ordering.
Q: Why does Agomelatine require liver function tests?
A: Agomelatine is metabolised by the liver and carries a hepatotoxicity risk. Baseline LFTs before starting and periodic monitoring during treatment are mandatory — do not take this medicine if you have pre-existing liver disease.
Q: How is Depurch different from SSRIs?
A: Depurch works through melatonin and serotonin receptor modulation rather than serotonin reuptake inhibition. It has no sexual dysfunction, no significant weight gain, and specifically improves sleep — advantages not shared by most SSRIs. See Antidepressants collection.
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Usage & Benefits
- Unique melatonergic antidepressant — not an SSRI — acts on MT1/MT2 and 5-HT2C receptors
- Improves sleep architecture and restores circadian rhythm alongside antidepressant effect
- No sexual dysfunction and no significant weight gain vs SSRIs
- Taken at bedtime with no daytime sedation
- Effective for major depressive disorder with comorbid insomnia
How To Use
1. Take one Depurch 25mg tablet once daily at bedtime as prescribed by your psychiatrist.
2. Swallow whole with water — do not crush or chew.
3. Take at the same time each night for consistent melatonergic activity.
4. Liver function tests are required before starting — arrange with your doctor before your first dose.
FAQs
Is Depurch 25mg available without a prescription in Pakistan?
No. It is a prescription-only (Rx) psychiatric medicine. Submit your valid prescription at sales@derma.pk or WhatsApp +92-320-5999650 before ordering.
Why must I get liver function tests before taking Depurch?
Agomelatine carries a hepatotoxicity risk. Baseline liver function tests (LFTs) before starting and periodic monitoring during treatment are mandatory. Do not use in patients with hepatic impairment.
How is Agomelatine different from SSRIs like Sertraline?
Agomelatine acts on melatonin and serotonin receptors rather than blocking serotonin reuptake. It improves sleep, has no sexual side effects, and no significant weight gain — differentiators not shared by most SSRIs.
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