Silo M 50/500mg Tablet – Sitagliptin + Metformin for Type 2 Diabetes
- Contains Sitagliptin 50mg + Metformin 500mg — starter-dose combination for type 2 diabetes by Macter International.
- Sitagliptin (DPP-4 inhibitor) + Metformin (biguanide) provide complementary glucose lowering.
- Starter Metformin dose (500mg) for patients initiating combination therapy.
- Taken twice daily with meals to reduce gastrointestinal side effects.
- Prescription only — not for type 1 diabetes or significant renal impairment.
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Silo M 50/500mg Tablet – Sitagliptin + Metformin for Type 2 Diabetes
Description
Silo M 50/500mg Tablet – Sitagliptin + Metformin Starter Dose for Type 2 Diabetes
Silo M 50/500mg Tablets combine Sitagliptin 50mg and Metformin 500mg in a single fixed-dose tablet, manufactured by Macter International. This formulation is the standard starting point for patients transitioning to combination anti-diabetic therapy. Sitagliptin (DPP-4 inhibitor) enhances incretin-mediated insulin secretion, while Metformin 500mg (biguanide) reduces hepatic glucose output and improves insulin sensitivity — together providing dual-mechanism blood glucose control with a well-tolerated Metformin dose.
The 500mg Metformin dose is specifically chosen to minimise the gastrointestinal side effects (nausea, bloating, diarrhoea) that can occur when initiating Metformin therapy, especially in patients who are Metformin-naive. As tolerance improves and clinical targets require it, the prescribing doctor may step up to Silo M 50/1000mg Tablet for stronger control. Patients needing Sitagliptin monotherapy may use Silo 50mg instead.
Silo M 50/500mg should be taken twice daily with meals to further reduce GI side effects. All Silo variants are available at Derma.pk with authentic pharmacy-verified stock and delivery to Lahore, Karachi, Islamabad, and across Pakistan.
How to Order Silo M 50/500mg Tablet at Derma.pk
Order from derma.pk. Contact sales@derma.pk or WhatsApp +92-320-5999650. A valid prescription is required for purchase.
Usage & Benefits
- Gentler Introduction: Lower Metformin dose (500mg) for patients new to combination therapy or sensitive to higher doses.
- Dual Glucose Control: Sitagliptin and Metformin work through different mechanisms for comprehensive effect.
- Better Tolerability: Starter dose reduces risk of gastrointestinal side effects common with higher Metformin doses.
- Dose Escalation Pathway: Can be stepped up to Silo M 50/1000mg as tolerance and clinical need increase.
- Cardiovascular Safety: Both components have established cardiovascular safety data.
How To Use
1. Take as prescribed — typically twice daily with meals.
2. Swallow the tablet whole with a glass of water. Do not crush or chew.
3. Maintain a consistent dosing schedule for optimal blood sugar management.
4. Follow your doctor's dietary and exercise recommendations alongside medication.
5. Do not discontinue without medical advice, even if sugar readings improve.
FAQs
Who is Silo M 50/500mg suitable for?
It is typically prescribed for patients starting combination therapy or those who cannot tolerate higher Metformin doses.
When should I consider upgrading to the 1000mg dose?
Your doctor will assess your HbA1c and blood sugar response after a few months. The dose may be stepped up to Silo M 50/1000mg if needed.
Does this tablet cause weight gain?
Metformin may help with modest weight management, and Sitagliptin is weight-neutral, so significant weight gain is not typical.
Can I take this if I have kidney problems?
Metformin requires adequate kidney function. Your doctor will assess renal function before prescribing.
Is a prescription required?
Yes. This is a prescription-only anti-diabetic combination medicine.
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