Tinabin Terbinafine 250mg Tablets — Antifungal Treatment

Terbinafine is a potent allylamine antifungal with a broad spectrum of activity. Tinabin Tablets by Derma Tecno deliver 250mg of Terbinafine Hydrochloride BP per film-coated tablet, providing effective treatment for fungal infections of the skin, hair, and nails.

Composition

Each film-coated Tinabin Tablet contains Terbinafine Hydrochloride (Terbinafine HCl BP) equivalent to 250mg of Terbinafine. Available in 125mg and 250mg strengths.

Properties

Terbinafine, an allylamine, works by interfering specifically with fungal sterol biosynthesis at an early stage. This interference leads to a deficiency in ergosterol, an essential component of fungal cell membranes, and results in intracellular accumulation of squalene, ultimately causing fungal cell death. Terbinafine acts by inhibiting squalene epoxidase in fungal cell membranes, making it an effective fungicide against dermatophytes, molds, and certain dimorphic fungi. Depending on the yeast species, it can be either fungicidal or fungistatic.

Pharmacokinetics

Tinabin Tablets are orally administered and rapidly absorbed. A single 250mg dose results in peak plasma concentration within two hours. Terbinafine has a high binding affinity to plasma proteins (99%) and readily distributes to the skin, hair follicles, and nails. It is secreted in sebum, ensuring high concentrations in these areas. Terbinafine also penetrates the nail plate, making it effective against onychomycosis (nail fungal infections). The drug is metabolized into nonfungicidal metabolites and excreted in the urine. Its elimination half-life is approximately 17 hours.

Indications

Tinabin Tablets are indicated for the treatment of:

• Fungal infections of the skin, hair, and nails caused by dermatophytes (e.g., Trichophyton, Microsporum, Epidermophyton)
• Ringworm (tinea corporis, tinea cruris, tinea pedis, and tinea capitis)
• Yeast infections of the skin caused by Candida albicans
• Onychomycosis (fungal nail infections) caused by dermatophyte fungi

Dosage and Administration

The dosage of Tinabin Tablets varies depending on the age and weight of the patient and the type of infection being treated. Generally, for adults, a daily dose of 250mg is recommended. Children's doses range from 62.5mg to 250mg, depending on their weight. The duration of treatment also varies based on the type and severity of the infection, ranging from 2 to 6 weeks for skin infections to several months for onychomycosis.

Precautions

• Patients with chronic liver disease should avoid Tinabin Tablets due to the potential risk of hepatotoxicity.
• Pretreatment liver function tests should be conducted for all patients.
• It is not recommended during pregnancy and lactation, and breastfeeding should be avoided while taking Terbinafine.
• Patients with renal impairment should be prescribed half the recommended dose.
• Healthcare providers should educate patients about potential side effects, including gastrointestinal symptoms and liver dysfunction.
• Terbinafine can interact with certain medications, including warfarin, rifampin, and cimetidine, affecting prothrombin time and drug clearance.
• Limited information exists on interactions with other drugs, such as diuretics, beta-blockers, and oral contraceptives.

Side Effects

Patients generally tolerate Tinabin Tablets well. Common side effects include gastrointestinal symptoms (nausea, dyspepsia, abdominal pain), loss of taste, and mild liver dysfunction.

Overdosage

In case of overdose, symptoms may include nausea, epigastric pain, and dizziness. Treatment involves administering activated charcoal and other supportive measures like gastric lavage and fluid replacement, if necessary.

Storage

Keep Tinabin Tablets below 30°C, protect from heat, light, and moisture. Keep out of reach of children.

Tinabin Terbinafine 250mg is a trusted most-loved antifungal available from Power Brands at Derma.pk. A prescription is required for this medication.