Vegadon SR 3mg Tablet – Paliperidone
Vegadon SR 3mg Tablet contains Paliperidone 3mg sustained-release, an atypical antipsychotic (D2/D3 + 5-HT2A antagonist) and the active metabolite of risperidone. It does not require hepatic CYP metabolism, making it suitable for patients with variable CYP2D6 activity. Indicated for schizophrenia and schizoaffective disorder; prescription only (Rx).
Pay in 3 Installments of
Rs.
504
Vegadon Sr 3mg Tablet – Paliperidone
Description
What is Vegadon SR 3mg?
Vegadon SR 3mg Tablet contains Paliperidone 3mg in a sustained-release formulation. Paliperidone is the active metabolite of risperidone and belongs to the atypical antipsychotic drug class. It is indicated for the treatment of schizophrenia and schizoaffective disorder in adults.
How Does Vegadon SR Work?
Paliperidone acts as a dopamine D2 and D3 receptor antagonist and a serotonin 5-HT2A receptor antagonist. This dual mechanism modulates dopaminergic and serotonergic neurotransmission in the mesolimbic and mesocortical pathways. Unlike risperidone, paliperidone does not require hepatic CYP2D6 metabolism, reducing inter-patient variability. The SR matrix allows once-daily dosing with stable plasma concentrations.
Uses of Vegadon SR 3mg
Vegadon SR 3mg is indicated for: acute and maintenance treatment of schizophrenia; schizoaffective disorder (as monotherapy or adjunct to mood stabilisers or antidepressants); reducing relapse frequency in chronic psychotic disorders. For patients managing Risperidone-based therapy, paliperidone offers a hepatically independent alternative.
Dosage & Administration
Recommended starting dose is 6mg once daily for schizophrenia; 3mg may be used in dose-sensitive patients. Administer with or without food; swallow whole, do not crush or chew. Dose adjustments should be made in steps of 3mg at intervals of at least 5 days. Renal impairment requires dose reduction. Always follow your prescribing physician's instructions.
Side Effects
Common side effects include akathisia, extrapyramidal symptoms (dose-related), somnolence, headache, tachycardia, and weight gain. Prolactin elevation is prominent and may cause galactorrhoea, amenorrhoea, or sexual dysfunction. Metabolic effects (dyslipidaemia, hyperglycaemia) and QTc prolongation have been reported. Rare but serious: neuroleptic malignant syndrome (NMS), tardive dyskinesia.
Precautions
Monitor fasting blood glucose and lipids at baseline and periodically. Use caution in patients with pre-existing QTc prolongation, cardiovascular disease, or renal impairment. Avoid in severe renal impairment (CrCl <10 mL/min). Not recommended during pregnancy or lactation without clear clinical need. May impair driving and operating machinery. Prescription only (Rx). Consult your doctor before use. See also Vegadon SR 6mg for higher-dose paliperidone therapy.
Frequently Asked Questions
Q: Can Vegadon SR 3mg be split or crushed?
A: No. The tablet uses a sustained-release matrix; splitting or crushing destroys the delivery mechanism and causes rapid drug release.
Q: Does Vegadon SR cause weight gain?
A: Weight gain and metabolic effects are class-related risks with paliperidone. Monitor weight, BMI, and metabolic parameters regularly.
Q: Is Vegadon SR 3mg available without a prescription in Pakistan?
A: No. Vegadon SR 3mg is a prescription-only medicine. A valid prescription is required for dispensing.
Usage & Benefits
- Treats positive and negative symptoms of schizophrenia
- Indicated for schizoaffective disorder as monotherapy or adjunct
- Sustained-release matrix ensures once-daily dosing and stable plasma levels
- No significant hepatic CYP2D6 metabolism — fewer drug interactions
- Reduces relapse frequency in chronic psychotic disorders
- Prescription-grade antipsychotic available in Pakistan
How To Use
Take Vegadon SR 3mg once daily in the morning with or without food. Swallow the tablet whole — do not crush, split, or chew, as this destroys the sustained-release mechanism. Your doctor may adjust your dose in 3mg increments at intervals of at least 5 days. Do not stop taking this medicine suddenly without consulting your physician. Prescription required.
FAQs
Can Vegadon SR 3mg tablet be split or crushed?
No. Splitting or crushing destroys the sustained-release matrix and causes an abrupt, potentially dangerous drug release. Always swallow whole.
Does Vegadon SR 3mg cause weight gain?
Weight gain is a recognised class effect of paliperidone. Monitor weight and metabolic parameters (blood glucose, lipids) regularly with your doctor.
Is a prescription required to buy Vegadon SR 3mg in Pakistan?
Yes. Vegadon SR 3mg is a prescription-only medicine (Rx). A valid doctor's prescription is required.
Dermatologist Recommended
Healer's Pharma Minoxidil 5% + Finasteride 0.25% Hair Regrowth Spray
0.25% Finasteride Topical Hair Loss Spray by Healer's Pharma
