VERTICIL TABLET 250mg PACK OF 10 TABLETS
VERTICIL TABLET (Terbinafine, Hydrochloride)
VERTICIL tablets contain Terbinafine Hydrochloride BP, available in 125 mg and 250 mg strengths, effective against a wide range of fungal infections
VERTICIL is rapidly absorbed, with peak plasma concentrations reached within hours. It binds strongly to plasma proteins and accumulates in skin, hair, and nails
It is used to treat onychomycosis (fungal nail infections), tinea capitis, and various skin fungal infections
The recommended dosage varies by age and type of infection, with treatment durations ranging from 2 to 12 weeks
VERTICIL should be used cautiously in patients with liver disease or impaired renal function. Careful monitoring for potential side effects is essential during treatment. Always consult a healthcare professional for personalized guidance
What You Should Know About VERTICIL TABLET
Introduction:
Before you start your VERTICIL TABLET medication, it's essential to have a complete understanding of what it is, how it works, and when it should be used This article provides comprehensive information about VERTICIL TABLET, covering its composition, pharmacology, indications, dosage, and more
Composition:
Each tablet of VERTICIL contains Terbinafine Hydrochloride BP, available in two strengths, 125 mg and 250 mg Terbinafine is an allylamine with a broad spectrum of activity against fungal pathogens affecting the skin, hair, and nails, including dermatophytes like Trichophyton, Microspore, yeasts of the Candida genus, and more It exhibits fungicidal and fungistatic effects, inhibiting fungal sterol biosynthesis and leading to cellular accumulation of squalene
Pharmacokinetics:
VERTICIL is rapidly absorbed after oral administration, with peak plasma concentrations achieved within hours Its bioavailability is moderately affected by food but doesn't require dose adjustment Terbinafine strongly binds to plasma proteins and penetrates skin and nails effectively It's metabolized by several cytochrome P450 enzymes, primarily CYP2C9, CYP1A2, CYP3A4, CYP2CB, and CYP2C19 The elimination half-life is approximately 17 hours, with no age dependent changes observed in SteadyState plasma concentrations
Indications:
VERTICIL is indicated for treating onychomycosis (fungal nail infections) caused by dermatophyte fungi, tinea capitis, and various fungal infections of the skin, such as tinea corporis, tinea curries, tinea pedis, and Candida yeast infections
Dosage:
The dosage of VERTICIL varies depending on the patient's age and the type of infection:
- Children under 20 kg: 625 mg (half a 125 mg tablet) once daily
- Children between 20 and 40 kg: 125 mg (one 125 mg tablet) once daily
- Children over 40 kg: 250 mg (two 125 mg tablets) once daily
- Adults: 250 mg once a day
Duration of Treatment:
The duration of treatment depends on the type of infection:
- Tinea pedis, tinea corporis, tinea cruris: 2 to 4 weeks
- Cutaneous candidiasis: 2 to 4 weeks
- Tinea capitis: 4 weeks
- Onychomycosis: 6 to 12 weeks
For onychomycosis, the treatment duration can be extended in some cases, depending on the response and outgrowth of healthy nail tissue
Use in Special Populations:
Elderly patients: No evidence suggests different dosages or side effects in the elderly Consider evaluating liver or kidney function in this age group
Children: VERTICIL is well tolerated in children above 2 years of age
Contraindications:
Do not use VERTICIL if you are allergic to terbinafine or any of its ingredients.
Special Warnings and Precautions:
Before starting VERTICIL, assess patients with preexisting liver disease. They may experience hepatotoxicity, so monitor them for symptoms like nausea, fatigue, abdominal pain, or jaundice. Adjust dosages for patients with impaired renal function.
Drug Interactions:
VERTICIL may interact with various medications, such as those metabolized by cytochrome P450 enzymes Close monitoring and possible dosage adjustments are necessary when combined with certain drugs
Pregnancy and Lactation:
Pregnant women should only use VERTICIL if the potential benefits outweigh the risks.
Adverse Effects:
VERTICIL can be generally well tolerated, although some people may experience common side effects such as gastrointestinal symptoms, taste disturbances, and mild abdominal pain. In rare cases, more serious side effects like hepatobiliary dysfunction, serious skin reactions, and hematological disorders have been reported. Overdosing on VERTICIL can also lead to symptoms like headache and nausea.
Conclusion:
VERTICIL is an antifungal medication effective in treating various fungal infections Understanding its composition, indications, dosage, and potential side effects is crucial for safe and effective use Always consult with a healthcare professional for personalized guidance on VERTICIL treatment
Usage and Benefits of VERTICIL Tablet
- Effective Antifungal Treatment: VERTICIL is highly effective against various fungal infections such as onychomycosis, tinea capitis, and skin infections like tinea pedis and tinea corporis.
- Broad-Spectrum Action: It is a broad-spectrum antifungal agent, acting against dermatophytes, yeast infections, and molds.
- Convenient Dosage: VERTICIL comes in tablet form, with a once-daily dosage for easy adherence to treatment.
- Well-Tolerated: Most patients tolerate VERTICIL well, with only mild to moderate side effects such as gastrointestinal issues and taste disturbances.
- Proven Efficacy: With proper usage, VERTICIL ensures a high cure rate, particularly in treating onychomycosis and other fungal infections.
How to Use VERTICIL Tablet
Follow these instructions for proper use of VERTICIL Tablet:
- For children under 20 kg, take 625 mg (half a 125 mg tablet) once daily.
- For children between 20-40 kg, take 125 mg (one 125 mg tablet) once daily.
- For children over 40 kg and adults, take 250 mg (two 125 mg tablets) once daily.
- For onychomycosis, treatment may last 6 to 12 weeks, while skin infections like tinea pedis can be treated within 2 to 4 weeks.
- Always take the tablet with food to maximize absorption and avoid esophageal irritation. Do not exceed the recommended dose.
Consult your healthcare provider for specific dosage recommendations based on your condition.
1. What is VERTICIL Tablet used for?
VERTICIL Tablet, containing Terbinafine Hydrochloride, is primarily used to treat various fungal infections such as onychomycosis (nail infections), tinea capitis (scalp infection), and other skin infections like tinea corporis, tinea cruris, tinea pedis, and Candida yeast infections.
2. How does VERTICIL work?
VERTICIL works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This results in the accumulation of squalene in fungal cells, disrupting their function and causing cell death, making it effective against a wide range of fungal infections.
3. What is the recommended dosage of VERTICIL Tablet?
The dosage of VERTICIL varies by age and infection type. For children under 20 kg, the recommended dose is 625 mg once daily. For children between 20-40 kg, it's 125 mg daily. Adults and children over 40 kg are recommended to take 250 mg once daily. The duration depends on the infection, ranging from 2 to 12 weeks.
4. What are the potential side effects of VERTICIL?
Common side effects of VERTICIL include gastrointestinal issues like nausea and mild abdominal pain, taste disturbances, and rash. Rare but serious side effects may include hepatobiliary dysfunction, skin reactions, and hematological disorders. Always monitor for adverse reactions and consult your healthcare provider if symptoms persist.
5. Can VERTICIL be used during pregnancy or breastfeeding?
VERTICIL should only be used during pregnancy if the potential benefits outweigh the risks. It is also not recommended for breastfeeding as Terbinafine can be excreted in breast milk. Always consult your doctor before using VERTICIL if you are pregnant or nursing.